Eberhardt Olaf
Klinikum Bogenhausen Klinik für Neurologie.
Fortschr Neurol Psychiatr. 2018 May;86(5):290-300. doi: 10.1055/s-0043-122600. Epub 2018 Feb 28.
The urgency and intensity of therapeutic response to a hypertensive crisis are governed by the presence or absence of acute end-organ damage, which define hypertensive emergency and hypertensive urgency, respectively. In case of hypertensive urgency a slow and moderate lowering of blood pressure by oral antihypertensive agents seems adequate, while the approach to hypertensive emergency has to be tailored to the specific type of organ failure. Optimal blood pressure management in the context of neurovascular emergencies is made difficult by contradictory data from observational and interventional studies. It might prove advantageous to individualize treatment according to characteristics such as the location of persistent vessel occlusion or the presence of collaterals. Reversible posterior encephalopathy may present with atypical features that might make diagnosis difficult. Clevidipine might be a welcome supplement to current intravenous antihypertensive agents in neurological disease.
对高血压急症治疗反应的紧迫性和强度取决于是否存在急性终末器官损害,这分别定义了高血压急症和高血压亚急症。对于高血压亚急症,口服抗高血压药物缓慢、适度降低血压似乎就足够了,而高血压急症的治疗方法必须根据器官衰竭的具体类型进行调整。神经血管急症中最佳血压管理因观察性和干预性研究的数据相互矛盾而变得困难。根据持续性血管闭塞的位置或侧支循环的存在等特征进行个体化治疗可能证明是有益的。可逆性后部脑病可能表现出非典型特征,这可能使诊断变得困难。在神经疾病中,左西孟旦可能是目前静脉抗高血压药物的一个受欢迎的补充。