Department of Epidemiology and Public Health, Faculty of Medicine and pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Faculty of Science Dhar Mehraz, Laboratory of Microbiology and Molecular Biology, Fez, Morocco.
BMC Cancer. 2018 Mar 1;18(1):233. doi: 10.1186/s12885-018-4139-6.
This systematic review was conducted to explain the association between dairy products and colorectal cancer (CRC) risk in Middle Eastern and North African countries (MENA).
The database consulted were PubMed, Clinical Trials, and Cochrane to extract the relevant studies published till the 31stof December 2016, using inclusion and exclusion criteria according to Prisma Protocol. The characteristics of these studies comprised the consumption of all types of dairy products in relation to CRC risk.
Seven studies were included in this review. For dairy products overall, no significant association was found. Regarding modern dairy products, included studies found controversial results with OR = 9.88 (95% CI: 3.80-24.65) and OR = 0.14 (95% CI: 0.02-0.71). A positive association was reported between traditional dairy products and CRC risk, to OR = 18.66 (95% CI: 3.06-113.86) to OR = 24 (95% CI: 1.74-330.82) to ORa = 1.42 (95% CI: 0.62-3.25), p = 0.03. Calcium was inversely associated with the CRC risk with OR = 0.08 (95% CI: 0.04-0.17).
This is the first systematic review which illustrated the association between dairy consumption and CRC risk in MENA region. The results were inconsistent and not always homogeneous. Further specified studies may be warranted to address the questions about the association between CRC and dairy products in a specific context of MENA region.
本系统评价旨在解释中东和北非国家（MENA）乳制品与结直肠癌（CRC）风险之间的关联。
检索了 PubMed、ClinicalTrials 和 Cochrane 数据库，以提取截至 2016 年 12 月 31 日发表的相关研究，根据 Prisma 议定书使用纳入和排除标准。这些研究的特点是研究了所有类型的乳制品与 CRC 风险的关系。
本综述纳入了 7 项研究。对于乳制品总体而言，未发现显著相关性。关于现代乳制品，纳入的研究结果存在争议，OR=9.88（95%CI：3.80-24.65）和 OR=0.14（95%CI：0.02-0.71）。传统乳制品与 CRC 风险呈正相关，OR=18.66（95%CI：3.06-113.86）至 OR=24（95%CI：1.74-330.82）至 ORa=1.42（95%CI：0.62-3.25），p=0.03。钙与 CRC 风险呈负相关，OR=0.08（95%CI：0.04-0.17）。
这是首个系统评价，说明了 MENA 地区乳制品消费与 CRC 风险之间的关联。结果不一致，并不总是一致。进一步的具体研究可能需要解决关于 MENA 地区特定背景下 CRC 与乳制品之间关联的问题。
