Folayan Morenike Oluwatoyin, Haire Bridget, Allman Dan, Yakubu Aminu, Afolabi Muhammed O
Institute of Public Health, Obafemi Awolowo University, Ile-Ife, Nigeria.
Kirby Institute, University of New South Wales, Sydney, Australia.
BMC Res Notes. 2018 Mar 1;11(1):159. doi: 10.1186/s13104-018-3263-3.
This paper presents the results of the consultations conducted with various stakeholders in Africa and other experts to document community perspectives on the types of research to be prioritised in outbreak conditions. The Delphi method was used to distill consensus.
Our consultations highlighted as key, the notion that in an infectious disease outbreak situation, the need to establish an evidence base on how to reduce morbidity and mortality in real time takes precedence over the production of generalizable knowledge. Research studies that foster understanding of how disease transmission could be prevented in the future remain important, implementation research that explores how to mitigate the impact of outbreaks in the present should be prioritized. Clinical trials aiming to establish the safety profile of therapeutic interventions should be limited during the acute phase of an epidemic with high fatality-and should preferably use adaptive designs. We concluded that community members have valuable perspectives to share about research priorities during infectious disease emergencies. Well designed consultative processes could help identify these opinions.
本文展示了与非洲的各类利益相关者以及其他专家进行磋商的结果，以记录社区对于在疫情爆发情况下应优先开展的研究类型的看法。采用德尔菲法来提炼共识。
我们的磋商突出了一个关键观点，即在传染病爆发的情况下，实时建立关于如何降低发病率和死亡率的证据基础比生成可推广的知识更为重要。促进对未来如何预防疾病传播的理解的研究仍然很重要，但应优先开展探索如何减轻当前疫情影响的实施研究。在高致死率的疫情急性期，旨在确定治疗性干预安全性的临床试验应受到限制，并且最好采用适应性设计。我们得出结论，社区成员在传染病紧急情况期间对于研究重点有宝贵的观点可供分享。精心设计的磋商过程有助于识别这些意见。
