Université Paris Descartes, Sorbonne Paris Cité, Équipe d'accueil VIgilance FAtigue SOMmeil (VIFASOM) EA 7330, France; Université Paris Descartes, Sorbonne Paris Cité, APHP, HUPC, Hôtel Dieu, Centre du Sommeil et de la Vigilance, Paris, France.
Université Paris Descartes, Sorbonne Paris Cité, Équipe d'accueil VIgilance FAtigue SOMmeil (VIFASOM) EA 7330, France; Institut de Recherche Biomédicale des Armées (IRBA), Brétigny-sur-Orge, France; Rythm SAS, Paris, France.
Sleep Med Rev. 2018 Oct;41:113-132. doi: 10.1016/j.smrv.2018.01.008. Epub 2018 Feb 5.
In recent decades, increasing evidence has positioned slow-wave sleep (SWS) as a major actor in neurophysiological phenomena such as glucose metabolism, hormone release, immunity and memory. This proposed role for SWS, coupled with observations of impaired SWS in several pathologies as well as in aging, has led some researchers to implement methods that could specifically enhance SWS. This review aims to gather the current knowledge extending from the cell to the clinic, in order to construct an overview of what is currently known about so-called SWS. We slowly expand the view from the molecular processes underlying SWS to the cell unit and assembly to cortical manifestations. We then describe its role in physiology and cognition to finally assess its association with clinical aspects. Finally, we address practical considerations for several techniques that could be used to manipulate SWS, in order to improve our understanding of SWS and possibly help the development of treatments for SWS clinical disorders.
近几十年来，越来越多的证据将慢波睡眠（SWS）定位为神经生理现象的主要参与者，如葡萄糖代谢、激素释放、免疫和记忆。SWS 的这种作用，加上在几种病理状态以及衰老中观察到的 SWS 受损，促使一些研究人员实施能够特异性增强 SWS 的方法。本综述旨在从细胞到临床收集目前的知识，以便对所谓的 SWS 的现有知识进行概述。我们从 SWS 的基础分子过程缓慢扩展到细胞单元和集合到皮质表现。然后，我们描述其在生理学和认知中的作用，以最终评估其与临床方面的关联。最后，我们讨论了几种可能用于操纵 SWS 的技术的实际考虑因素，以提高我们对 SWS 的理解，并可能有助于开发 SWS 临床障碍的治疗方法。
