Toyokawa Gouji, Yamada Yuichi, Tagawa Tetsuzo, Kinoshita Fumihiko, Kozuma Yuka, Matsubara Taichi, Haratake Naoki, Takamori Shinkichi, Akamine Takaki, Hirai Fumihiko, Oda Yoshinao, Maehara Yoshihiko
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Anticancer Res. 2018 Mar;38(3):1821-1825. doi: 10.21873/anticanres.12421.
BACKGROUND/AIM: Spread through air spaces (STAS) is a novel invasive pattern of lung cancer, especially adenocarcinoma and squamous cell carcinoma. However, its frequency and significance in patients with resected small cell lung cancer (SCLC) remains unclear.
A total of 30 patients with resected SCLC were analyzed for STAS. STAS was classified as either no STAS, low STAS (1-4 single cells or clusters of STAS), or high STAS (≥5 single cells or clusters of STAS). We evaluated the association between STAS and clinicopathological characteristics and postoperative survivals.
Among 30 patients, 5 (17%), 6 (20%) and 19 (63%) were classified as having no, low and high STAS, respectively. Fisher's exact test demonstrated no significant associations between the positivity for STAS and clinicopathological characteristics. No significant differences were observed in recurrence-free and overall survival between STAS-negative/low and STAS-high patients.
STAS was frequently observed in patients with resected SCLC.
背景/目的：气腔播散（STAS）是肺癌尤其是腺癌和鳞状细胞癌的一种新型侵袭模式。然而，其在接受手术切除的小细胞肺癌（SCLC）患者中的发生率及意义仍不明确。
对30例接受手术切除的SCLC患者进行STAS分析。STAS分为无STAS、低STAS（1 - 4个单个细胞或STAS细胞簇）或高STAS（≥5个单个细胞或STAS细胞簇）。我们评估了STAS与临床病理特征及术后生存率之间的关联。
30例患者中，分别有5例（17%）、6例（20%）和19例（63%）被分类为无、低和高STAS。Fisher精确检验显示STAS阳性与临床病理特征之间无显著关联。STAS阴性/低和STAS高的患者在无复发生存率和总生存率方面未观察到显著差异。
在接受手术切除的SCLC患者中经常观察到STAS。
