Di Silverio F, Sciarra F
J Steroid Biochem. 1986 Nov;25(5B):773-9. doi: 10.1016/0022-4731(86)90307-9.
Surgical castration combined to cyproterone acetate treatment in patients with advanced prostatic carcinoma, gives satisfactory clinical results in 75% of the cases, with a follow-up period of 12-59 months. Histological tumour grading, tissue dihydrotestosterone (DHT) concentrations and DNA distribution by flow-cytometry in the tumoral cells are significantly correlated with the clinical response to hormonal therapy, whilst cytosol androgen receptors are not. 17 cases with DHT levels greater than 1.8 ng/g tissue are in remission (COR, POR or OS), whereas 5 cases with DHT levels less than 1.8 ng/g are in progression. In the responder group diploid DNA pattern is found in 20 cases and aneuploidy in 7, whilst in the not responder group aneuploidy was found in 5 cases and diploidy in 2. In conclusion histological grading and measurement of DNA and DHT in tumour tissue may be complementary in the prospective identification of the hormonally dependent tumours, which may benefit of the combined endocrine therapy suppressing androgens of testicular and adrenal origin.
对于晚期前列腺癌患者，手术去势联合醋酸环丙孕酮治疗，在12至59个月的随访期内，75%的病例取得了满意的临床效果。肿瘤组织学分级、组织二氢睾酮（DHT）浓度以及肿瘤细胞中通过流式细胞术检测的DNA分布与激素治疗的临床反应显著相关，而细胞溶质雄激素受体则不然。17例DHT水平高于1.8 ng/g组织的患者病情缓解（完全缓解、部分缓解或病情稳定），而5例DHT水平低于1.8 ng/g的患者病情进展。在有反应的组中，20例呈现二倍体DNA模式，7例为非整倍体；而在无反应的组中，5例为非整倍体，2例为二倍体。总之，肿瘤组织的组织学分级以及DNA和DHT的测量，在前瞻性识别激素依赖性肿瘤方面可能具有互补性，这些肿瘤可能受益于联合内分泌治疗，抑制睾丸和肾上腺来源的雄激素。
