Giuliani L, Pescatore D, Giberti C, Martorana G, Natta G
Eur Urol. 1980;6(3):145-8. doi: 10.1159/000473313.
We report the results from 106 patients with extracapsular (stage C) or widespread (stage D) prostatic cancer, who were treated with cyproterone acetate and orchiectomy and followed for 5 years. As controls we used 40 patients, chosen at random, with stage C and stage D cancer of the prostate gland who were treated with stilbestrol and orchiectomy. The survival rate is improved in patients treated with cyproterone acetate and orchiectomy compared to the patients treated with stilbestrol and orchiectomy. Treatment with cyproterone seems more effective in those patients with low-stage and low-grade prostatic cancer. The side effects of this therapy are less and milder than those described in estrogenic treatment alone or with orchiectomy.
我们报告了106例患有包膜外（C期）或广泛性（D期）前列腺癌患者的治疗结果，这些患者接受了醋酸环丙孕酮和睾丸切除术，并随访了5年。作为对照，我们随机选择了40例患有C期和D期前列腺癌的患者，他们接受了己烯雌酚和睾丸切除术。与接受己烯雌酚和睾丸切除术的患者相比，接受醋酸环丙孕酮和睾丸切除术的患者生存率有所提高。醋酸环丙孕酮治疗似乎对低分期和低分级前列腺癌患者更有效。该疗法的副作用比单独使用雌激素治疗或雌激素与睾丸切除术联合治疗时所描述的副作用更少且更轻微。
