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使用卡麦角林治疗泌乳素瘤期间发生垂体卒中。

Pituitary Apoplexy during Treatment of Prolactinoma with Cabergoline.

作者信息

Ghadirian Hesam, Shirani Mohamad, Ghazi-Mirsaeed Shahab, Mohebi Saleh, Alimohamadi Maysam

机构信息

Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Asian J Neurosurg. 2018 Jan-Mar;13(1):93-95. doi: 10.4103/1793-5482.181130.

DOI:10.4103/1793-5482.181130
PMID:29492132
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5820907/
Abstract

Pituitary apoplexy is a rare clinical presentation caused by infarction of the pituitary gland or adenoma with or without hemorrhage. Although pituitary apoplexy is usually spontaneous, one of the predisposing factors is treatment with dopamine agonists, especially bromocriptine. The occurrence of apoplexy during cabergoline therapy is reported much less frequently. In this article, we report a 34-year-old man with macroprolactinomas who developed sudden visual deterioration due to pituitary apoplexy 1 year after initiation of cabergoline therapy. He was treated via endoscopic trans-sphenoidal surgery and his visual status recovered dramatically.

摘要

垂体卒中是一种由垂体梗死或腺瘤伴或不伴出血引起的罕见临床表现。尽管垂体卒中通常是自发的,但诱发因素之一是使用多巴胺激动剂治疗,尤其是溴隐亭。卡麦角林治疗期间发生卒中的报道则少得多。在本文中,我们报告了一名34岁的大泌乳素瘤男性患者,在开始卡麦角林治疗1年后因垂体卒中出现突然的视力恶化。他接受了内镜经蝶窦手术治疗,视力状况显著恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/5820907/14664e673ea0/AJNS-13-93-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/5820907/57021b27725f/AJNS-13-93-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/5820907/8d9d3fb85bab/AJNS-13-93-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/5820907/a9b88cb1136a/AJNS-13-93-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/5820907/14664e673ea0/AJNS-13-93-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/5820907/57021b27725f/AJNS-13-93-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/5820907/8d9d3fb85bab/AJNS-13-93-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/5820907/a9b88cb1136a/AJNS-13-93-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/5820907/14664e673ea0/AJNS-13-93-g004.jpg

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Pituitary apoplexy: a comprehensive analysis of 93 cases across functioning and non-functioning pituitary adenomas from a single-center.垂体卒中:单中心功能性和非功能性垂体腺瘤 93 例综合分析。
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本文引用的文献

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2
Apoplexy of pituitary adenomas: the perfect storm.垂体腺瘤卒中:完美风暴。
J Neurosurg. 2015 Jun;122(6):1444-9. doi: 10.3171/2014.10.JNS141720. Epub 2015 Apr 10.
3
Pituitary apoplexy associated with cabergoline therapy.与卡麦角林治疗相关的垂体卒中。
孕期巨大垂体卒中的延迟诊断:一例报告
Int J Surg Case Rep. 2022 Oct;99:107706. doi: 10.1016/j.ijscr.2022.107706. Epub 2022 Sep 27.
4
A scoping review to understand the indications, effectiveness, and limitations of cabergoline in radiological and biochemical remission of prolactinomas.一项范围综述,旨在了解卡麦角林在泌乳素瘤放射学和生化缓解方面的适应证、有效性及局限性。
Indian J Endocrinol Metab. 2021 Nov-Dec;25(6):493-506. doi: 10.4103/ijem.ijem_338_21. Epub 2022 Feb 17.
5
Treatment and therapeutic strategies for pituitary apoplexy in pregnancy: a case series.妊娠期垂体卒中的治疗和治疗策略:病例系列研究。
J Med Case Rep. 2021 May 27;15(1):289. doi: 10.1186/s13256-021-02892-5.
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Comparative analysis of pituitary adenoma with and without apoplexy in pediatric and adolescent patients: a clinical series of 80 patients.儿童和青少年垂体腺瘤伴与不伴卒中的对比分析:80 例临床系列。
Neurosurg Rev. 2022 Feb;45(1):491-498. doi: 10.1007/s10143-021-01551-z. Epub 2021 Apr 29.
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Identification of driver genes and key pathways of prolactinoma predicts the therapeutic effect of genipin.鉴定催乳素瘤的驱动基因和关键通路可预测京尼平的治疗效果。
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