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成人幕上脑室外间变性室管膜瘤:治疗方法与临床综述

Adult Supratentorial Extraventricular Anaplastic Ependymoma: Therapeutic Approach and Clinical Review.

作者信息

Lavrador José Pedro, Oliveira Edson, Teixeira Joaquim Cruz, Lopes José Pedro, Pimentel José, Carvalho Manuel Herculano

机构信息

Department of Neurosurgical, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.

Neuropathology Laboratory, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.

出版信息

Asian J Neurosurg. 2018 Jan-Mar;13(1):105-109. doi: 10.4103/1793-5482.181121.

Abstract

We report a 69-year-old patient with left paresthesia and hemiparesis. Magnetic resonance imaging revealed a right frontoparietal cystic tumor. A subtotal surgical resection was performed, and an Ommaya reservoir was left in place. The pathological diagnosis was supratentorial extraventricular anaplastic ependymoma. Radiation therapy was administered, and Ommaya reservoir drainages were performed. Four months after, her clinical status deteriorated after a reservoir drainage and image revealed an acute hemorrhage. An additional resection was carried out, and chemotherapy was undergone. One month later the tumor relapsed and the patient died 18 months after initial diagnosis. Some poor prognostic factors have been suggested in the literature: Young age, incomplete tumor resection - eloquent area location, histological anaplasia, supratentorial, and extraventricular locations. Ommaya reservoirs may be used in cystic lesions as a temporary measure only. Surgery is the mainstay of therapy with adjuvant radiotherapy and/or chemotherapy.

摘要

我们报告了一名69岁患有左侧感觉异常和偏瘫的患者。磁共振成像显示右侧额顶叶囊性肿瘤。进行了次全手术切除,并留置了一个Ommaya储液器。病理诊断为幕上脑室外间变性室管膜瘤。给予了放射治疗,并进行了Ommaya储液器引流。四个月后,在一次储液器引流后她的临床状况恶化,影像学显示急性出血。进行了再次切除,并接受了化疗。一个月后肿瘤复发,患者在初次诊断后18个月死亡。文献中提出了一些不良预后因素:年轻、肿瘤切除不完全 - 功能区位置、组织学间变、幕上和脑室外位置。Ommaya储液器仅可作为囊性病变的临时措施使用。手术是主要治疗手段,并辅以放疗和/或化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cce3/5820861/ffc5288a8342/AJNS-13-105-g001.jpg

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