Labeeuw M, Pozet N, Zech P, Traeger J
Presse Med. 1987;16(1):25-7.
The inhibitory effect of magnesium on the first stages of renal calcium stone formation is modest in vitro and more pronounced in experimental in vivo studies. Magnesium deficiency has not yet been convincingly demonstrated in man. However, urinary magnesium concentrations are abnormally low in relation to urinary calcium concentrations in more than 25% of patients with kidney stones. A supplementary magnesium intake corrects this abnormality and prevents the recurrence of stones. Magnesium seems to be as effective against stone formation as diuretics. The modalities of magnesium therapy still have to be determined and its results to be confirmed. Magnesium, possibly added to drinking water, may well play a role in the primary prevention of renal calcium stones.
镁对肾钙结石形成早期阶段的抑制作用在体外实验中较为适度，而在体内实验研究中更为显著。人体中尚未令人信服地证明存在镁缺乏的情况。然而，超过25%的肾结石患者尿镁浓度相对于尿钙浓度异常低。补充镁摄入量可纠正这种异常并预防结石复发。镁在预防结石形成方面似乎与利尿剂同样有效。镁疗法的具体方式仍有待确定，其效果也有待证实。镁可能添加到饮用水中，很可能在肾钙结石的一级预防中发挥作用。
