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本文引用的文献

1
Growth rate of vestibular schwannoma.前庭神经鞘瘤的生长速率
J Clin Neurosci. 2016 Oct;32:1-8. doi: 10.1016/j.jocn.2016.05.003. Epub 2016 Jul 20.
2
Conservative management of vestibular schwannomas of 15 to 31 mm intracranial diameter.颅内直径15至31毫米的前庭神经鞘瘤的保守治疗
J Laryngol Otol. 2014 Sep;128(9):752-8. doi: 10.1017/S0022215114001315. Epub 2014 Aug 14.
3
Epidemiology and natural history of vestibular schwannomas.前庭神经鞘瘤的流行病学与自然史
Otolaryngol Clin North Am. 2012 Apr;45(2):257-68, vii. doi: 10.1016/j.otc.2011.12.008. Epub 2012 Feb 28.
4
Growth of untreated vestibular schwannoma: a prospective study.未治疗前庭神经鞘瘤的生长:一项前瞻性研究。
J Neurosurg. 2012 Apr;116(4):706-12. doi: 10.3171/2011.12.JNS111662. Epub 2012 Jan 20.
5
Active surveillance for prostate cancer compared with immediate treatment: an economic analysis.主动监测与即刻治疗前列腺癌的经济学分析比较。
Cancer. 2012 Jul 15;118(14):3512-8. doi: 10.1002/cncr.26688. Epub 2011 Dec 16.
6
Predictors of volumetric growth and auditory deterioration in vestibular schwannomas followed in a wait and scan policy.随访观察策略下听神经鞘瘤体积增长和听力恶化的预测因素。
Otol Neurotol. 2011 Feb;32(2):338-44. doi: 10.1097/MAO.0b013e3182040d9f.
7
True incidence of vestibular schwannoma?前庭神经鞘瘤的真实发病率?
Neurosurgery. 2010 Nov;67(5):1335-40; discussion 1340. doi: 10.1227/NEU.0b013e3181f22660.
8
Vestibular schwannoma: role of conservative management.前庭神经鞘瘤:保守治疗的作用
J Laryngol Otol. 2010 Mar;124(3):251-7. doi: 10.1017/S0022215109992362. Epub 2009 Dec 11.
9
A protocol for the conservative management of vestibular schwannomas.
Otol Neurotol. 2009 Apr;30(3):381-385. doi: 10.1097/mao.0b013e31819a8df6.
10
The natural history of vestibular schwannoma.前庭神经鞘瘤的自然病史。
Otol Neurotol. 2006 Jun;27(4):547-52. doi: 10.1097/01.mao.0000217356.73463.e7.

稳定型前庭神经鞘瘤监测的标准化路径

A standardised pathway for the surveillance of stable vestibular schwannoma.

作者信息

Shapey J, Barkas K, Connor S, Hitchings A, Cheetham H, Thomson S, U-King-Im J M, Beaney R, Jiang D, Barazi S, Obholzer R, Thomas Nwm

机构信息

King's College Hospital NHS Foundation Trust, UK , UK.

出版信息

Ann R Coll Surg Engl. 2018 Mar;100(3):216-220. doi: 10.1308/rcsann.2017.0217.

DOI:10.1308/rcsann.2017.0217
PMID:29493353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5930097/
Abstract

Introduction Conservative management of patients with a stable vestibular schwannoma (VS) places a significant burden on National Health Service (NHS) resources and yet patients' surveillance management is often inconsistent. Our unit has developed a standardised pathway to guide surveillance imaging of patients with stable VS. In this article, we provide the basis for our imaging protocol by reviewing the measurement, natural history and growth patterns of VS, and we present a cost analysis of implementing the pathway both regionally and nationally. Methods Patients with an extrameatal VS measuring ≤20mm in maximal diameter receive magnetic resonance imaging (MRI) six months after their index imaging, followed by three annual MRI scans, two two-year interval MRI scans, a single three-year interval MRI scan and then five-yearly MRI scans to be continued lifelong. Patients with purely intrameatal tumours follow the same protocol but the initial six-month imaging is omitted. A cost analysis of the new pathway was modelled on our unit's retrospective data for 2015 and extrapolated to reflect the cost of VS surveillance nationally. Results Based on an estimation that imaging surveillance would last approximately 25 years (+/- 10 years), the cost of implementing our regional surveillance programme would be £151,011 per year (for 99 new referrals per year) and it would cost the NHS £1,982,968 per year if implemented nationally. Conclusions A standardised surveillance pathway promotes safe practice in the conservative management of VS. The estimated cost of a national surveillance programme compares favourably with other tumour surveillance initiatives, and would enable the NHS to provide a safe and economical service to patients with VS.

摘要

引言

对前庭神经鞘瘤(VS)稳定的患者进行保守治疗给国民医疗服务体系(NHS)资源带来了沉重负担,而且患者的监测管理往往不一致。我们科室制定了标准化流程来指导VS稳定患者的监测成像。在本文中,我们通过回顾VS的测量方法、自然病史和生长模式,为我们的成像方案提供依据,并对在地区和全国范围内实施该流程进行成本分析。方法:最大直径≤20mm的外耳道外VS患者在初次成像后6个月接受磁共振成像(MRI)检查,随后每年进行3次MRI扫描,每两年进行2次MRI扫描,每三年进行1次MRI扫描,然后每五年进行1次MRI扫描并持续终身。纯耳道内肿瘤患者遵循相同方案,但省略初次6个月的成像检查。根据我们科室2015年的回顾性数据对新流程进行成本分析,并进行外推以反映全国VS监测的成本。结果:基于成像监测预计持续约25年(±10年)的估计,实施我们的区域监测计划每年的成本为151,011英镑(每年99例新转诊患者),如果在全国范围内实施,NHS每年将花费1,982,968英镑。结论:标准化监测流程促进了VS保守治疗中的安全实践。全国监测计划的估计成本与其他肿瘤监测举措相比具有优势,并且将使NHS能够为VS患者提供安全且经济的服务。