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在肯尼亚的初级医疗保健设施中,将钙和铁叶酸补充剂相结合以预防妊娠子痫前期和贫血的可行性。

Feasibility of integrating calcium and iron-folate supplementation to prevent preeclampsia and anemia in pregnancy in primary healthcare facilities in Kenya.

机构信息

Program in International Nutrition, Cornell University, Ithaca, New York, USA.

Africa Regional Office - Nutrition International, Nairobi, Kenya.

出版信息

Matern Child Nutr. 2018 Feb;14 Suppl 1(Suppl 1). doi: 10.1111/mcn.12437.

DOI:10.1111/mcn.12437
PMID:29493897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6866141/
Abstract

Calcium (Ca) supplementation to prevent preeclampsia can save maternal and newborn lives, but there are no program models for integration into existing antenatal care platforms. We used a program impact pathway model to guide the design of integrated Ca and iron-folate (IFA) supplementation in Kenya. We provided healthcare providers with job aids (posters and counseling cards), trained them on counseling techniques and supplementation guidelines, and developed behavior change materials for pregnant women (pill-taking calendars). We allocated health facilities to prescribe either 1.0 or 1.5 g/day Ca, with standard IFA. We collected implementation data from 16 facilities and 990 women. We also explored effects of supplementation on percentage of the population meeting recommended daily allowance. Supplements and job aids were available during 90% of facility spot-check episodes; calendar availability was lower (78%). Over 98% of clients received Ca and IFA supplements, but only 76% received enough Ca supplements to last between antenatal care visits. Among clients that still had pills by return date, adherence was 77% and 83% for the IFA and Ca regimen, respectively. When 1.5 g/day of Ca supplements were prescribed, over 75% of participants met recommended daily allowance. Only 54% met the recommended daily allowance when 1.0 g was prescribed. This study illustrates a systematic approach for integrating Ca supplementation into primary healthcare and demonstrates that such integration is feasible when contextual bottlenecks are addressed. Policy makers and program planners should pay attention to supply chain, healthcare worker dispensing behavior, and appropriateness of regimen for their settings.

摘要

钙(Ca)补充剂可预防子痫前期,从而挽救母婴生命,但目前尚无将其纳入现有产前保健平台的方案模式。我们使用项目影响途径模型来指导肯尼亚将 Ca 和铁叶酸(IFA)补充剂纳入整合的设计。我们为医疗保健提供者提供了工作辅助工具(海报和咨询卡),对他们进行了咨询技巧和补充剂使用指南的培训,并为孕妇开发了行为改变材料(服药日历)。我们为卫生机构分配了处方 1.0 或 1.5g/天 Ca,以及标准 IFA。我们从 16 个机构和 990 名妇女那里收集了实施数据。我们还探索了补充剂对满足建议日摄入量人群比例的影响。在 90%的设施抽查期间,均提供补充剂和工作辅助工具;日历的可用性较低(78%)。超过 98%的客户接受了 Ca 和 IFA 补充剂,但只有 76%的客户接受了足够的 Ca 补充剂,可维持两次产前保健之间的需求。在返回日期仍有药丸的客户中,分别有 77%和 83%的客户遵守了 IFA 和 Ca 方案的用药规定。当处方 1.5g/天 Ca 补充剂时,超过 75%的参与者符合建议的日摄入量。当处方 1.0g Ca 时,只有 54%符合建议的日摄入量。这项研究说明了将 Ca 补充剂纳入初级卫生保健的系统方法,并表明当解决了具体背景下的瓶颈问题时,这种整合是可行的。政策制定者和方案规划者应关注供应链、医疗保健工作者的分发行为以及方案对其环境的适宜性。

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本文引用的文献

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With adaptation, the WHO guidelines on calcium supplementation for prevention of pre-eclampsia are adopted by pregnant women.经改编后,世界卫生组织关于钙补充预防子痫前期的指南被孕妇采用。
Matern Child Nutr. 2018 Apr;14(2):e12521. doi: 10.1111/mcn.12521. Epub 2017 Nov 28.
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A Simplified Regimen Compared with WHO Guidelines Decreases Antenatal Calcium Supplement Intake for Prevention of Preeclampsia in a Cluster-Randomized Noninferiority Trial in Rural Kenya.在肯尼亚农村进行的一项整群随机非劣效性试验中,与世界卫生组织指南相比,一种简化方案可减少预防子痫前期的产前钙补充剂摄入量。
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Perinatal Mortality Due to Pre-Eclampsia in Africa: A Comprehensive and Integrated Approach Is Needed.非洲子痫前期导致的围产期死亡率:需要一种全面综合的方法。
Glob Health Sci Pract. 2016 Jun 27;4(2):350-1. doi: 10.9745/GHSP-D-16-00054. Print 2016 Jun 20.
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Hematol Oncol Clin North Am. 2016 Apr;30(2):247-308. doi: 10.1016/j.hoc.2015.11.002.
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Calcium Supplementation to Prevent Preeclampsia: Translating Guidelines into Practice in Low-Income Countries.补充钙预防子痫前期:在低收入国家将指南转化为实践
Adv Nutr. 2016 Mar 15;7(2):275-8. doi: 10.3945/an.115.010736. Print 2016 Mar.
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