Miner Brianna, Grigg William S., Hart Elise H.
Advocate Christ Medical Center
Parkview Medical Center
Wellens syndrome describes a pattern of electrocardiographic (ECG) changes, particularly deeply inverted or biphasic T waves in leads V2-V3, that is highly specific for critical, proximal stenosis of the left anterior descending (LAD) coronary artery. It is alternatively known as anterior, descending, T-wave syndrome. Typically when patients with Wellens syndrome present to the emergency department they are pain-free, and usually cardiac enzymes are normal or only slightly elevated. However, it is important to recognize the ECG patterns as these patients are at high risk for impending large anterior wall acute myocardial infarction. In fact, when Drs. De Zwaan, Wellens, and colleagues first identified the syndrome in the early 1980s, they noted that 75% of patients with these ECG findings went on to develop acute, anterior, wall, myocardial infarction within weeks if they were treated with only medical management. Definitive treatment typically involves cardiac catheterization with percutaneous coronary intervention (PCI) to relieve the occlusion.
Wellens综合征描述了一种心电图（ECG）变化模式，特别是V2-V3导联中深倒置或双向T波，这对左前降支（LAD）冠状动脉的严重近端狭窄具有高度特异性。它也被称为前降T波综合征。通常，当患有Wellens综合征的患者到急诊科就诊时，他们没有疼痛，并且通常心肌酶正常或仅略有升高。然而，识别这些心电图模式很重要，因为这些患者即将发生大面积前壁急性心肌梗死的风险很高。事实上，当德·兹万博士、韦伦斯博士及其同事在20世纪80年代初首次发现该综合征时，他们指出，有这些心电图表现的患者如果仅接受药物治疗，75%会在数周内发展为急性前壁心肌梗死。明确的治疗通常包括进行心脏导管插入术及经皮冠状动脉介入治疗（PCI）以解除阻塞。
