非酒精性脂肪性肝病血清代谢组学特征研究：研究与临床展望
Study of the Serum Metabolomic Profile in Nonalcoholic Fatty Liver Disease: Research and Clinical Perspectives.
作者信息
Gitto Stefano, Schepis Filippo, Andreone Pietro, Villa Erica
机构信息
Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola-Malpighi, 40138 Bologna, Italy.
Research Centre for the Study of Hepatitis, University of Bologna, 40138 Bologna, Italy.
出版信息
Metabolites. 2018 Feb 24;8(1):17. doi: 10.3390/metabo8010017.
Abstract
In recent years, metabolomics has attracted great scientific attention. The metabolomics methodology might permit a view into transitional phases between healthy liver and nonalcoholic steatohepatitis. Metabolomics can help to analyze the metabolic alterations that play a main role in the progression of nonalcoholic steatohepatitis. Lipid, glucose, amino acid, and bile acid metabolism should be widely studied to understand the complex pathogenesis of nonalcoholic steatohepatitis. The discovery of new biomarkers would be important for diagnosis and staging of liver disease as well as for the assessment of efficacy of new drugs. Here, we review the metabolomics data regarding nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. We analyzed the main studies regarding the application of metabolomics methodology in the complex context of nonalcoholic steatohepatitis, trying to create a bridge from the basic to the clinical aspects.
摘要
近年来，代谢组学已引起科学界的广泛关注。代谢组学方法可能有助于洞察健康肝脏与非酒精性脂肪性肝炎之间的过渡阶段。代谢组学有助于分析在非酒精性脂肪性肝炎进展中起主要作用的代谢改变。应广泛研究脂质、葡萄糖、氨基酸和胆汁酸代谢，以了解非酒精性脂肪性肝炎的复杂发病机制。发现新的生物标志物对于肝病的诊断和分期以及新药疗效评估都将具有重要意义。在此，我们综述了关于非酒精性脂肪性肝病和非酒精性脂肪性肝炎的代谢组学数据。我们分析了在非酒精性脂肪性肝炎复杂背景下应用代谢组学方法的主要研究，试图搭建起从基础到临床各方面的桥梁。
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本文引用的文献
1
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Clin Sci (Lond). 2019 Feb 5;133(3):409-423. doi: 10.1042/CS20171039. Print 2019 Feb 14.
2
Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes.二甲基胍基戊酸是肝脂肪的标志物，并可预测糖尿病。
J Clin Invest. 2017 Dec 1;127(12):4394-4402. doi: 10.1172/JCI95995. Epub 2017 Oct 30.
3
The use of obeticholic acid for the management of non-viral liver disease: current clinical practice and future perspectives.奥贝胆酸用于非病毒性肝病的治疗：当前的临床实践和未来展望。
Expert Rev Gastroenterol Hepatol. 2018 Feb;12(2):165-171. doi: 10.1080/17474124.2018.1399060. Epub 2017 Nov 3.
4
Specificities of Human Hepatocellular Carcinoma Developed on Non-Alcoholic Fatty Liver Disease in Absence of Cirrhosis Revealed by Tissue Extracts ¹H-NMR Spectroscopy.通过组织提取物¹H-NMR光谱揭示的非酒精性脂肪性肝病无肝硬化情况下发生的人肝细胞癌的特异性
Metabolites. 2017 Sep 22;7(4):49. doi: 10.3390/metabo7040049.
5
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Nutr Metab (Lond). 2017 Sep 2;14:58. doi: 10.1186/s12986-017-0213-3. eCollection 2017.
6
Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice.胆固醇诱导的非肥胖非酒精性脂肪肝病小鼠的代谢组学特征。
Sci Rep. 2017 Jul 21;7(1):6120. doi: 10.1038/s41598-017-05040-6.
7
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Nutrients. 2017 Jun 22;9(7):642. doi: 10.3390/nu9070642.
8
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9
Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model.从常见大鼠模型看人类非酒精性脂肪性肝病进展的代谢组学特征区分
Obesity (Silver Spring). 2017 Jun;25(6):1069-1076. doi: 10.1002/oby.21855. Epub 2017 Apr 28.
10
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