喷雾干燥马铃薯汁作为一种具有胃肠道保护作用的潜在功能性食品成分。
Spray-Dried Potato Juice as a Potential Functional Food Component with Gastrointestinal Protective Effects.
机构信息
Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznań, Poland.
Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego Str., 60-627 Poznań, Poland.
出版信息
Nutrients. 2018 Feb 24;10(2):259. doi: 10.3390/nu10020259.
BACKGROUND
Peptic ulcer disease, including its complications and functional dyspepsia, are prevalent gastrointestinal diseases, etiopathogenesis of which is associated with mucosal inflammation. Research into new therapeutics capable of preventing or curing gastrointestinal mucosal damage has been steadily developing over past decades. This study was undertaken to evaluate whether a spray-dried preparation of potato juice is applicable for treating and preventing gastrointestinal mucosal damage.
METHODS
We assessed potential protective effects of spray-dried potato juice (SDPJ) against gut inflammation in the co-culture Caco-2/RAW264.7 system, as well as a gastroprotective activity in a rat model of gastric ulceration.
RESULTS
The obtained results indicated that SDPJ down-regulates lipopolysaccharide (LPS)-induced mRNA expression and protein production of proinflammatory cytokines IL-6 and TNF-α in the co-culture model. Moreover, SDPJ provided dose-dependent protection against LPS-induced disruption of intestinal barrier integrity. In rats, five-day pretreatment with SDPJ in doses of 200 mg/kg and 500 mg/kg suppressed HCl/ethanol-induced TNF-α expression in gastric mucosa by 52% and 35%, respectively. In addition, the pretreatment with the lower dose of SDPJ reduced the incidence of ulcers (by 34%) expressed as ulcer index.
CONCLUSION
The spray-dried potato juice appears to be an attractive candidate for ameliorating inflammation-related diseases of the gastrointestinal tract.
背景
消化性溃疡病（包括其并发症和功能性消化不良）是常见的胃肠道疾病，其发病机制与黏膜炎症有关。在过去的几十年中，一直在研究能够预防或治疗胃肠道黏膜损伤的新疗法。本研究旨在评估喷雾干燥的马铃薯汁（SDPJ）是否可用于治疗和预防胃肠道黏膜损伤。
方法
我们评估了喷雾干燥的马铃薯汁（SDPJ）在 Caco-2/RAW264.7 共培养物系统中对肠道炎症的潜在保护作用，以及在大鼠胃溃疡模型中对胃保护活性。
结果
结果表明，SDPJ 可下调共培养物模型中脂多糖（LPS）诱导的促炎细胞因子 IL-6 和 TNF-α 的 mRNA 表达和蛋白产生。此外，SDPJ 对 LPS 诱导的肠屏障完整性破坏具有剂量依赖性的保护作用。在大鼠中，用 SDPJ 预处理 5 天，剂量为 200mg/kg 和 500mg/kg 时，可分别抑制 HCl/乙醇诱导的 TNF-α 在胃黏膜中的表达 52%和 35%。此外，较低剂量的 SDPJ 预处理可降低溃疡发生率（降低 34%），表现为溃疡指数。
结论
喷雾干燥的马铃薯汁似乎是改善胃肠道炎症性疾病的有吸引力的候选物。
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