Konstat-Korzenny Enrique, Ascencio-Aragón Jorge Alberto, Niezen-Lugo Sebastian, Vázquez-López Rosalino
Departamento de Microbiología del Centro de Investigación en Ciencias de la Salud (CICSA) Facultad de Ciencias de la Salud, Universidad Anáhuac México Campus Norte. Av. Universidad Anáhuac 46 Col. Lomas Anáhuac Huixquilucan, Estado de México 52786, México.
Med Sci (Basel). 2018 Feb 27;6(1):19. doi: 10.3390/medsci6010019.
To assess the possibility of using the antimalarial drug artemisinin and its synthetic derivatives as antineoplastic drugs. A Pubmed and Google Scholar (1983-2018) search was performed using the terms artemisinin, cancer, artesunate and Case reports and original research articles, review articles, and clinical trials in both humans and animals were evaluated. Both in vitro and in vivo clinical trials and case reports have shown promising activity of the artemisinin drug derivatives in treating certain types of cancer. However, the reported articles are few, and therefore not statistically significant. The minimal toxicity shown in clinical trials and case reports, along with the selective cytotoxic activity of the compounds, make them possible cancer therapies due to the emerging evidence of the drug's effectiveness.
评估使用抗疟药物青蒿素及其合成衍生物作为抗肿瘤药物的可能性。利用“青蒿素”“癌症”“青蒿琥酯”等关键词在PubMed和谷歌学术（1983 - 2018年）数据库中进行检索。对人类和动物的病例报告、原始研究文章、综述文章及临床试验进行评估。体外和体内临床试验以及病例报告均显示青蒿素药物衍生物在治疗某些类型癌症方面具有可观的活性。然而，所报道的文章数量较少，因此无统计学意义。临床试验和病例报告中显示的最低毒性，以及这些化合物的选择性细胞毒性活性，鉴于该药物有效性的新证据，使其有可能成为癌症治疗方法。
