Lax E R, Ghraf R, Schriefers H
Endokrinologie. 1979;74(2):153-7.
Five sexually differentiated enzyme activities of hepatic steroid metabolism (cytoplasmic 17 beta-hydroxysteroid dehydrogenase, 5 beta-reductase; microsomal 3 alpha- and 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase) were investigated in intact, gonadectomized and hypophysectomized rats after administration of a single dose of oestradiol valerate. Oestradiol administration caused a partial or complete feminization of these activities in intact male rats. The influence of oestradiol on these activities in gonadectomized rats was determined by the mode of sex hormone-dependent regulation of the individual activity: the most prominent effects were seen in the oestrogen-dependent activities (17 beta-hydroxysteroid dehydrogenase, 5 beta-reductase); no effect was seen in the completely androgen-dependent 3 alpha-hydroxysteroid dehydrogenase because gonadectomy alone was sufficient to cause complete feminization of the activity. Oestradiol administration had no effect on the activities of hypophysectomized rats. The fact that oestrogen administration to intact male rats caused greater changes than prepuberal gonadectomy demonstrates that oestrogen action is more than simple suppression of testicular function.
在完整、去性腺和垂体切除的大鼠中，单次给予戊酸雌二醇后，研究了肝脏类固醇代谢的五种性别分化酶活性（细胞质17β-羟基类固醇脱氢酶、5β-还原酶；微粒体3α-和3β-羟基类固醇脱氢酶以及5α-还原酶）。给予雌二醇使完整雄性大鼠的这些活性部分或完全女性化。雌二醇对去性腺大鼠这些活性的影响取决于个体活性的性激素依赖性调节模式：在雌激素依赖性活性（17β-羟基类固醇脱氢酶、5β-还原酶）中观察到最显著的影响；在完全雄激素依赖性的3α-羟基类固醇脱氢酶中未观察到影响，因为仅去性腺就足以使该活性完全女性化。给予雌二醇对垂体切除大鼠的活性没有影响。对完整雄性大鼠给予雌激素引起的变化比青春期前去性腺更大，这一事实表明雌激素的作用不仅仅是简单地抑制睾丸功能。
