影响催乳素分泌的药物对大鼠类固醇激素代谢中一些性别分化的肝脏和肾脏酶活性的影响。

Influence of drugs affecting prolactin secretion on some sexually differentiated hepatic and renal enzyme activities of steroid hormone metabolism in the rat.

作者信息

Lax E R, Ghraf R, Schriefers H, Wuttke W

出版信息

Arzneimittelforschung. 1980;30(8):1284-6.

Abstract

The effects of drugs known to modify hypophyseal release of prolactin [perphenazine, reserpine, DOPA, 2-bromo-alpha-ergocryptine-mesasilate (CB 154)] were tested on sexually differentiated enzymes of hepatic (microsomal 3 alpha- and 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase) and renal (cytoplasmic 17 beta-hydroxysteroid dehydrogenase) steroid metabolism whose activities had previously been shown to be influenced by prolactin administration to hypophysectomized rats. None of the drugs affected the renal enzyme activity. Reserpine caused a feminization of all three hepatic activities, whereas perphenazine only affected 5 alpha-reductase. Such changes are in accordance with the hypothesis that prolactin acts as a "feminizing factor" for these activities. However, the two drugs known to decrease prolactin secretion (DOPA, CB 154) also caused some feminization. Based on changes in seminal vesicle weight, this effect of DOPA might be due to alterations in the peripheral androgen concentration.

摘要

已知能改变垂体催乳素释放的药物（奋乃静、利血平、多巴、2-溴-α-麦角隐亭甲磺酸盐（CB 154））对肝脏（微粒体3α-和3β-羟基类固醇脱氢酶以及5α-还原酶）和肾脏（细胞质17β-羟基类固醇脱氢酶）性分化类固醇代谢酶的作用进行了测试，这些酶的活性先前已表明会受到垂体切除大鼠注射催乳素的影响。这些药物均未影响肾脏酶活性。利血平导致所有三种肝脏酶活性出现女性化，而奋乃静仅影响5α-还原酶。这些变化符合催乳素作为这些酶活性“女性化因子”的假说。然而，已知能减少催乳素分泌的两种药物（多巴、CB 154）也导致了一些女性化现象。根据精囊重量的变化，多巴的这种作用可能是由于外周雄激素浓度的改变所致。