Ohnishi K, Saito M, Nakayama T, Hatano H, Okuda K
Am J Gastroenterol. 1987 Feb;82(2):135-8.
In view of the variability in the magnitude of the response of portal venous pressure to vasopressin in man, we investigated the effect of vasopressin on portal hemodynamics in seven patients with portal hypertension by simultaneous catheterization of the portal and the hepatic vein and the measurement of portal venous flow by an echo-Doppler flowmetry. Infusion of vasopressin (0.3 U/min) significantly decreased portal venous pressure (-36%), the gradient between portal venous pressure and free hepatic venous pressure (-50.6%), and portal venous flow (-54.3%) but did not reduce mean arterial pressure and pulse rate. Thus, vasopressin seems to decrease portal venous pressure by reducing portal venous flow.
鉴于人体门静脉压力对血管加压素反应程度存在变异性，我们通过同时对门静脉和肝静脉进行插管，并采用超声多普勒血流仪测量门静脉血流，研究了血管加压素对7例门静脉高压患者门静脉血流动力学的影响。输注血管加压素（0.3 U/分钟）可显著降低门静脉压力（-36%）、门静脉压力与游离肝静脉压力之间的梯度（-50.6%）以及门静脉血流（-54.3%），但未降低平均动脉压和脉率。因此，血管加压素似乎是通过减少门静脉血流来降低门静脉压力的。
