Siri F M, McNamara J J
Am J Physiol. 1987 Feb;252(2 Pt 2):H442-7. doi: 10.1152/ajpheart.1987.252.2.H442.
Effects of chemical sympathectomy with 6-hydroxydopamine on left ventricular mass, norepinephrine content, and performance in aortic-constricted and sham-constricted rats were examined. Sympathectomy did not affect mean arterial pressure but it led to lower final body weights in aortic-constricted rats. Of the hypertensive aortic-constricted rats, those that had also been sympathectomized showed greater increases in left ventricular weight-to-body weight, right ventricular weight-to-body weight, and lung weight-to-body weight ratios. Left ventricular norepinephrine content was depressed by either sympathectomy or aortic constriction and was severely depleted by their combination. Sympathectomy had no effect on maximal cardiac output or left ventricular stroke work during rapid saline infusion. In aortic-constricted rats, however, it lowered heart rate during the infusion and increased left ventricular end-diastolic pressure at peak stroke work. This evidence suggests that elimination of the adrenergic nervous system's chronotropic influence promotes greater left ventricular filling, and the resultant increase in preload may importantly contribute to the stimulation of cardiac hypertrophy.
研究了用6-羟基多巴胺进行化学性交感神经切除对主动脉缩窄和假手术缩窄大鼠左心室质量、去甲肾上腺素含量及心脏功能的影响。交感神经切除不影响平均动脉压，但导致主动脉缩窄大鼠的最终体重降低。在高血压主动脉缩窄大鼠中，接受交感神经切除的大鼠左心室重量与体重、右心室重量与体重以及肺重量与体重的比值增加幅度更大。交感神经切除或主动脉缩窄均可降低左心室去甲肾上腺素含量，二者联合作用则使其严重耗竭。在快速输注生理盐水期间，交感神经切除对最大心输出量或左心室每搏功无影响。然而，在主动脉缩窄大鼠中，交感神经切除可降低输注期间的心率，并在每搏功峰值时增加左心室舒张末期压力。这一证据表明，消除肾上腺素能神经系统的变时性影响可促进左心室更充分的充盈，由此导致的前负荷增加可能对心脏肥大的刺激起重要作用。
