Tomanek R J, Carlson D W, Palmer P J, Bhatnagar R K
Department of Anatomy, University of Iowa, Iowa City 52242.
Am J Physiol. 1987 Oct;253(4 Pt 2):H818-25. doi: 10.1152/ajpheart.1987.253.4.H818.
Peak left ventricular (LV) function, during rapid volume expansion, and cardiocyte structure were studied in rats with developing cardiac hypertrophy in response to Grollman hypertension (1 kidney, 1 figure 8) after chemical sympathectomy with 6-hydroxydopamine. This form of renovascular hypertension led to the same magnitude of hypertrophy in rats with or without sympathectomy. Indices of peak LV function, measured during acute volume expansion, tended to be normal or slightly higher in hypertensive rats than in controls. Sympathectomy in rats with hypertension significantly improved cardiac and stroke indices while decreasing total peripheral resistance at peak cardiac output. Despite similar magnitudes of LV hypertrophy (LVH) in the two hypertensive groups, cardiocytes in sympathectomized rats had higher mitochondrial volume densities and slightly lower myofibrillar volume densities. After regional sympathectomy of the anterior portion of the LV with phenol, mitochondrial volume density increased by 21% in hypertensive rats with LVH. These data indicate that, during the development of LVH in response to renovascular hypertension, sympathetic nerves do not contribute to the magnitude of LVH but may limit improvement in peak LV performance in response to increased preload. However, sympathetic nerves do play a role in the regulation of mitochondrial and myofibril growth.
在使用6-羟基多巴胺进行化学交感神经切除术后，对因格罗尔曼高血压（1肾，1个数字8模型）而发生心脏肥大的大鼠，研究了快速容量扩张期间的左心室（LV）功能峰值和心肌细胞结构。这种肾血管性高血压形式在有或没有交感神经切除术的大鼠中导致相同程度的肥大。在急性容量扩张期间测量的左心室功能峰值指标，高血压大鼠往往比对照组正常或略高。高血压大鼠的交感神经切除术显著改善了心脏和中风指标，同时在心脏输出峰值时降低了总外周阻力。尽管两个高血压组的左心室肥大（LVH）程度相似，但交感神经切除术后大鼠的心肌细胞线粒体体积密度较高，肌原纤维体积密度略低。用苯酚对左心室前部进行局部交感神经切除术后，患有左心室肥大的高血压大鼠线粒体体积密度增加了21%。这些数据表明，在因肾血管性高血压而发生左心室肥大的过程中，交感神经对左心室肥大的程度没有影响，但可能会限制左心室对增加前负荷的峰值性能改善。然而，交感神经在调节线粒体和肌原纤维生长方面确实发挥了作用。
