University of Thessaly, Faculty of Medicine, Laboratory of Biology, Larissa, Greece.
University of Thessaly, Faculty of Medicine, Laboratory of Cytogenetics and Molecular Genetics, Larissa, Greece.
Mech Ageing Dev. 2018 Apr;171:15-23. doi: 10.1016/j.mad.2018.02.006. Epub 2018 Feb 27.
MicroRNAs are small non-coding RNA species with the ability to post-transcriptionally control the expression of multiple genes, that have gained substantial interest because of their expression alterations that accompanies aging and possible age-related pathologies. Given the constant rise in the number of patients suffering from age-related diseases -due to the increase of the aging population in the western world- the exploration of the role of specific microRNAs in the etiopathology of these diseases is expected to have great impact. Degenerative arthritis or osteoarthritis is of the most common age-related diseases and possible the one with the most limited therapeutic options. In this review therefore, we highlight recent advances considering the implication of microRNAs in processes known to contribute to the development of this disease. We also critically present the analytical approaches adopted so far, in an attempt to facilitate the acknowledgment of the necessary experimental tactic that will lead to the establishment of microRNAs as biomarkers and/or therapeutic agents for this age-related pathology.
微小 RNA 是具有转录后调控多个基因表达能力的小非编码 RNA 种类，由于其在衰老和可能与年龄相关的病理过程中发生的表达改变而受到广泛关注。鉴于西方世界老年人口增加导致与年龄相关的疾病患者数量不断增加，探索特定微小 RNA 在这些疾病发病机制中的作用有望产生重大影响。退行性关节炎或骨关节炎是最常见的与年龄相关的疾病之一，也是可能治疗选择最有限的疾病之一。因此，在这篇综述中，我们强调了最近在微小 RNA 参与已知导致这种疾病发展的过程中的作用方面的进展。我们还批判性地介绍了迄今为止采用的分析方法，试图促进承认必要的实验策略，这将导致微小 RNA 作为这种与年龄相关的病理的生物标志物和/或治疗剂的确立。
