Zitelli B J, Alexander J, Taylor S, Miller K D, Howrie D L, Kuritsky J N, Perez T H, Van Thiel D H
Ann Intern Med. 1987 Mar;106(3):393-5. doi: 10.7326/0003-4819-106-3-393.
Pyrimethamine-sulfadoxine has been associated with severe and fatal cutaneous reactions as well as transient liver damage. We report the case of a patient who died of progressive hepatic failure caused by pyrimethamine-sulfadoxine administration. In addition, we summarize reports made to the Food and Drug Administration since 1982 that focus on hepatotoxic reactions to pyrimethamine-sulfadoxine. We suggest that fatal hepatic injury can occur after treatment with pyrimethamine-sulfadoxine and that physicians who prescribe the drug should be aware of this possibility.
乙胺嘧啶-磺胺多辛与严重及致命的皮肤反应以及短暂性肝损伤有关。我们报告了一例因使用乙胺嘧啶-磺胺多辛导致进行性肝衰竭而死亡的患者病例。此外，我们总结了自1982年以来向美国食品药品监督管理局提交的关于乙胺嘧啶-磺胺多辛肝毒性反应的报告。我们建议，使用乙胺嘧啶-磺胺多辛治疗后可能会发生致命性肝损伤，开具该药物的医生应意识到这种可能性。
