Alekseyev Kirill, Iannicello Armando, Amore Giuseppe, Rosenkranz Travis, Ross Marc K
Department of Medicine and Rehabilitation, Kingsbrook Jewish Medical Center, Brooklyn, NY, USA.
Oxf Med Case Reports. 2016 Aug 29;2016(8):omw046. doi: 10.1093/omcr/omw046. eCollection 2016 Aug.
Thymic carcinoma is a rare, aggressive neoplasm with low 5-year survival rates ranging from 28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report one patient, a 29-year-old African-American male, with thymic carcinoma with metastasis to the epidural space (with cord compression), multiple bony structures (T10-L1) and left supraclavicular lymph node. Immunohistochemical staining was CD5 and c-Kit positive, consistent with thymic carcinoma. Patient underwent T12-L1 laminectomy with tumor resection to relieve cord compression and leg numbness/weakness. Patient was deemed a good candidate for rehabilitation. Soon after starting a rehabilitation program, he quickly demonstrated gains in gait distance with little to no assistance. Follow-up appointments with oncology were scheduled, and further planning of radiation and chemotherapy treatments were discussed.
胸腺癌是一种罕见的侵袭性肿瘤，5年生存率较低，在28%至67%之间。原发性胸腺癌最初表现为脊柱或骨转移极为罕见。与胸腺瘤相比，胸腺癌的复发率更高，生存率更差。我们报告一例患者，为一名29岁的非裔美国男性，患有胸腺癌，已转移至硬膜外间隙（伴有脊髓压迫）、多个骨质结构（T10-L1）和左锁骨上淋巴结。免疫组化染色显示CD5和c-Kit阳性，符合胸腺癌表现。患者接受了T12-L1椎板切除术并切除肿瘤以缓解脊髓压迫和腿部麻木/无力。患者被认为是康复治疗的合适人选。在开始康复计划后不久，他在几乎无需帮助的情况下，很快就显示出行走距离有所增加。安排了与肿瘤科的后续预约，并讨论了放疗和化疗的进一步治疗计划。
