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恶性胸腺瘤酷似硬膜外脓肿的硬膜外转移:病例报告及文献综述

Epidural Metastasis in Malignant Thymoma Mimicking Epidural Abscess: Case Report and Literature Review.

作者信息

Kim Ji Yoon, Lee Young Seok, Kang Dong Ho, Kim Min Hye, Lee Jeong Hee, Lee Chul Hee, Park In Sung

机构信息

Department of Anesthesiology and Pain Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.

Department of Neurosurgery, Gyeongsang National University School of Medicine, Jinju, Korea.

出版信息

Korean J Spine. 2017 Dec;14(4):162-165. doi: 10.14245/kjs.2017.14.4.162. Epub 2017 Dec 31.

DOI:10.14245/kjs.2017.14.4.162
PMID:29301178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5769940/
Abstract

Thymoma and thymic carcinoma are rare epithelial tumors that originate from the thymus gland. Extrathoracic metastases occur in the liver, kidney, and bone in 1% to 15% of patients. Although thymoma and thymic carcinoma exhibit highly aggressive biological behavior, spinal metastasis is rare. We describe a 78-year-old man with left wrist and grasp weakness that occurred 7 days before admission. The patient underwent thymoma surgery 7 years ago and was cured. Magnetic resonance images showed a rim-enhanced mass in the C6-7-T1 epidural space. C6-7-T1 laminectomy was performed and the mass was removed. Histological examination was performed and patient was diagnosed with metastatic thymoma. The previous reported case occurred with involvement of the vertebral body or posterior element, but our case was mostly rim-enhanced and appeared as an abscess and intradural extramedullary tumor.

摘要

胸腺瘤和胸腺癌是起源于胸腺的罕见上皮性肿瘤。1%至15%的患者会出现肝、肾和骨的胸外转移。尽管胸腺瘤和胸腺癌表现出高度侵袭性的生物学行为,但脊柱转移却很罕见。我们描述了一名78岁男性,入院前7天出现左手腕及抓握无力。该患者7年前接受了胸腺瘤手术且已治愈。磁共振成像显示C6 - 7 - T1硬膜外间隙有环形强化肿块。进行了C6 - 7 - T1椎板切除术并切除了肿块。进行了组织学检查,患者被诊断为转移性胸腺瘤。先前报道的病例累及椎体或后部结构,但我们的病例大多为环形强化,表现为脓肿和硬脊膜外髓外肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60f/5769940/c352aaff852f/kjs-14-4-162f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60f/5769940/e011686340d3/kjs-14-4-162f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60f/5769940/2105c2c024d8/kjs-14-4-162f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60f/5769940/c352aaff852f/kjs-14-4-162f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60f/5769940/e011686340d3/kjs-14-4-162f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60f/5769940/2105c2c024d8/kjs-14-4-162f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60f/5769940/c352aaff852f/kjs-14-4-162f3.jpg

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引用本文的文献

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Eur Spine J. 2019 Jun;28(6):1520-1528. doi: 10.1007/s00586-019-05982-7. Epub 2019 May 7.
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Surgical management of spinal metastases of thymic carcinoma: A case report and literature review.胸腺癌脊柱转移瘤的外科治疗:1例报告及文献复习
Medicine (Baltimore). 2019 Jan;98(3):e14198. doi: 10.1097/MD.0000000000014198.
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Successful treatment of malignant thymoma with sacrum metastases: A case report and review of literature.

本文引用的文献

1
First description of cervical intradural thymoma metastasis.颈椎硬膜内胸腺瘤转移的首次描述。
World J Clin Cases. 2015 Nov 16;3(11):946-50. doi: 10.12998/wjcc.v3.i11.946.
2
Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart.《2015年世界卫生组织肺、胸膜、胸腺和心脏肿瘤分类》简介
J Thorac Oncol. 2015 Sep;10(9):1240-1242. doi: 10.1097/JTO.0000000000000663.
3
Delayed distant spinal metastasis in thymomas.胸腺瘤的延迟性远隔性脊柱转移。
骶骨转移恶性胸腺瘤的成功治疗:一例报告并文献复习
Medicine (Baltimore). 2018 Dec;97(51):e13796. doi: 10.1097/MD.0000000000013796.
Spine (Phila Pa 1976). 2013 Dec 15;38(26):E1709-13. doi: 10.1097/BRS.0000000000000029.
4
Thymoma and thymic carcinoma.胸腺瘤和胸腺癌。
Gen Thorac Cardiovasc Surg. 2012 Jan;60(1):1-12. doi: 10.1007/s11748-011-0814-0. Epub 2012 Jan 13.
5
Spinal carcinoid metastasis with dural invasion.脊柱类癌转移伴硬脑膜侵犯。
World Neurosurg. 2011 Nov;76(5):478.e7-478.e11. doi: 10.1016/j.wneu.2010.10.045.
6
Thymic carcinoma with primary spine metastasis.胸腺癌伴脊柱原发性转移。
J Clin Neurosci. 2011 Jun;18(6):840-2. doi: 10.1016/j.jocn.2010.08.038. Epub 2011 Mar 23.
7
Epidemiology of thymoma and associated malignancies.胸腺瘤及相关恶性肿瘤的流行病学。
J Thorac Oncol. 2010 Oct;5(10 Suppl 4):S260-5. doi: 10.1097/JTO.0b013e3181f1f62d.
8
Recurrent thymoma with a pleural dissemination invading the intervertebral foramen.复发性胸腺瘤伴胸膜播散并侵犯椎间孔。
Eur J Cardiothorac Surg. 2009 May;35(5):917-9. doi: 10.1016/j.ejcts.2009.01.036. Epub 2009 Mar 9.
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Thymic carcinoma: current concepts and histologic features.胸腺癌:当前概念与组织学特征
Hematol Oncol Clin North Am. 2008 Jun;22(3):393-407. doi: 10.1016/j.hoc.2008.03.002.
10
Thymoma metastatic to the extradural spine.胸腺瘤转移至硬膜外脊柱。
J Clin Neurosci. 2005 Sep;12(7):824-7. doi: 10.1016/j.jocn.2004.09.028.