Institute for Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany.
Clin Pharmacol Ther. 2019 Mar;105(3):625-640. doi: 10.1002/cpt.1057. Epub 2018 Apr 2.
Older persons may particularly benefit from pharmacogenetic diagnostics, but there is little clinical evidence on that question. We quantitatively analyzed the effects of age and genotype in drugs with consensus on a therapeutically relevant impact of a genotype. Assuming additive effects of age and genotype, drugs may be classified in groups with different priorities to consider either age, or genotype, or both, in therapy. Particularly interesting were those studies specifically analyzing the age-by-genotype interaction.
老年人可能特别受益于药物遗传学诊断，但在这个问题上几乎没有临床证据。我们定量分析了年龄和基因型在具有治疗相关基因型影响共识的药物中的作用。假设年龄和基因型的加性效应，药物可以分为不同优先级的组，在治疗中考虑年龄、基因型或两者。特别有趣的是那些专门分析年龄-基因型相互作用的研究。
