Translational Australian Clinical Toxicology (TACT) Research Group, Discipline of Pharmacology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, NSW, Australia.
Suicide Life Threat Behav. 2019 Feb;49(1):293-302. doi: 10.1111/sltb.12443. Epub 2018 Mar 2.
The aim of this study was to determine the relationship between alcohol co-ingestion in an index deliberate self-poisoning (DSP) episode with repeated DSP and subsequent suicide. A retrospective cohort study was conducted involving 5,669 consecutive index presentations to a toxicology service following DSP between January 1, 1996, and October 31, 2010. Records were probabilistically matched to National Coronial Information System data to identify subsequent suicide. Index DSPs were categorized on co-ingestion of alcohol, and primary outcomes analyzed were repetition of any DSP, rates of repeated DSP, time to first repeat DSP, and subsequent suicide. Co-ingestion of alcohol occurred in 35.9% of index admissions. There was no difference between those who co-ingested alcohol (ALC+) and those who did not co-ingest alcohol (ALC-) in terms of proportion of repeat DSP, number of DSP events, or time to first repeat DSP event. Forty-one (1.0%) cases were probabilistically matched to a suicide death; there was no difference in the proportion of suicide between ALC+ and ALC- at 1 or 3 years. There was no significant relationship between the co-ingestion of alcohol in an index DSP and subsequent repeated DSP or suicide. Clinically, this highlights the importance of mental health assessment of patients that present after DSP, irrespective of alcohol co-ingestion at the time of event.
本研究旨在确定在索引蓄意自我中毒（DSP）事件中同时摄入酒精与重复 DSP 以及随后自杀之间的关系。一项回顾性队列研究涉及 1996 年 1 月 1 日至 2010 年 10 月 31 日期间因 DSP 连续就诊的 5669 例毒理学服务索引。记录通过概率匹配国家尸检信息系统数据来识别随后的自杀。索引 DSP 根据酒精的共摄入情况进行分类，主要分析结果为任何重复 DSP、重复 DSP 的发生率、首次重复 DSP 的时间和随后的自杀。在索引入院中，有 35.9%的患者共摄入了酒精。在重复 DSP 的比例、DSP 事件的数量或首次重复 DSP 事件的时间方面，共摄入酒精的患者（ALC+）与未共摄入酒精的患者（ALC-）之间没有差异。有 41 例（1.0%）病例概率性匹配到自杀死亡；在 1 年或 3 年内，ALC+和 ALC-之间的自杀比例没有差异。在索引 DSP 中同时摄入酒精与随后的重复 DSP 或自杀之间没有显著关系。从临床角度来看，这强调了对 DSP 后就诊的患者进行心理健康评估的重要性，无论其在事件发生时是否共摄入酒精。
