Secrest S, Sharma A, Bugbee A
Department of Veterinary Biosciences and Diagnostic Imaging, University of Georgia College of Veterinary Medicine, Athens, GA.
Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, Athens, GA.
J Vet Intern Med. 2018 May;32(3):962-966. doi: 10.1111/jvim.14899. Epub 2018 Mar 2.
Diabetes mellitus (DM) is a common endocrinopathy in cats. No known diagnostic test or patient characteristic at the time of diagnosis can predict likely disease course, unlike in people in whom computed tomographic angiography (CTA) is used. No published data exist regarding the CTA appearance of the pancreas in cats with DM, and thus, it is unknown what if any CTA variables should be further assessed for associations with pancreatic endocrine function.
HYPOTHESIS/OBJECTIVES: A significant difference in pancreatic attenuation, volume, and size will be identified between normal cats and those with chronic DM on CTA.
Ten healthy control cats and 15 cats with naturally occurring DM present for >12 months.
Prospective cross-sectional study comparing pancreatic attenuation, enhancement pattern, size, volume, pancreatic volume-to-body weight ratio (V:BW), pancreatic arterial: portal phase ratio (A:P), time-to-arterial enhancement, and time-to-peak portal enhancement on CTA between sedated healthy control cats and those with chronic DM.
The pancreas in cats with chronic DM was significantly larger, had higher volume, higher V:BW, and shorter time-to-peak portal enhancement on CTA when compared to normal cats.
Peak portal enhancement time, pancreatic size, pancreatic volume, and V:BW can be used to differentiate normal sedated cats from those with chronic DM by CTA. These variables warrant further investigation to identify possible associations with endocrine function.
糖尿病（DM）是猫常见的内分泌疾病。与使用计算机断层血管造影（CTA）的人类不同，目前尚无已知的诊断测试或诊断时的患者特征能够预测猫糖尿病可能的病程。目前尚无关于糖尿病猫胰腺CTA表现的已发表数据，因此，尚不清楚哪些CTA变量（如果有的话）应进一步评估与胰腺内分泌功能的关联。
假设/目的：在CTA上，正常猫与慢性糖尿病猫之间的胰腺衰减、体积和大小将存在显著差异。
10只健康对照猫和15只自然发生糖尿病且病程超过12个月的猫。
一项前瞻性横断面研究，比较了镇静状态下健康对照猫和慢性糖尿病猫在CTA上的胰腺衰减、强化模式、大小、体积、胰腺体积与体重比（V:BW）、胰腺动脉期与门静脉期比值（A:P）、动脉期强化时间和门静脉期峰值强化时间。
与正常猫相比，慢性糖尿病猫的胰腺在CTA上明显更大，体积更大，V:BW更高，门静脉期峰值强化时间更短。
门静脉期峰值强化时间、胰腺大小、胰腺体积和V:BW可用于通过CTA区分正常镇静猫和慢性糖尿病猫。这些变量值得进一步研究，以确定与内分泌功能的可能关联。
