Division of Hepato-Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
J Gastrointest Surg. 2011 Mar;15(3):525-32. doi: 10.1007/s11605-010-1406-5. Epub 2010 Dec 23.
BACKGROUNS/AIMS: There are few studies about the assessment of pancreatic function using computed tomography (CT) volumetry. In this study, we examined the correlation between CT volumetry and endocrine parameters (blood glucose and HbA1c) of the pancreas.
A total of 68 patients underwent enhanced CT for pancreatic disease from January to December in 2008. In particular, we analyzed the correlation of diabetic status and pancreatic CT parameters at 1 year after pancreatoduodenectomy in 32 patients. CT parameters including volume, volume/body weight, arterial phase density, the arterial phase to portal phase density ratio (A/P ratio) of the pancreas, and size of pancreatic duct were also analyzed. Correlation between CT parameters and diabetic status was analyzed preoperatively and postoperatively by ANOVA test.
The preoperative diabetic status and parameters correlated well with arterial phase density (p = 0.004), A/P ratio, and pancreatic duct size (p < 0.0001). In the patients who underwent pancreatectomy, two out of 25 patients without preoperative diabetes mellitus (DM) had DM, and two out of seven patients with preoperative DM recovered from DM. Postoperative CT parameters correlated with the DM status 1 year after pancreatectomy.
CT is a useful modality for evaluation of the pancreatic endocrine function and could be used for the prediction of postoperative diabetic outcome.
目前关于使用计算机断层扫描（CT）容积法评估胰腺功能的研究较少。本研究旨在探讨胰腺 CT 容积与内分泌参数（血糖和 HbA1c）之间的相关性。
2008 年 1 月至 12 月期间，共有 68 例胰腺疾病患者接受了增强 CT 检查。特别分析了 32 例胰十二指肠切除术后 1 年患者的糖尿病状态与胰腺 CT 参数的相关性。还分析了胰腺的体积、体积/体重、动脉期密度、胰腺的动脉期到门静脉期密度比（A/P 比）以及胰管大小等 CT 参数。通过方差分析检验术前和术后 CT 参数与糖尿病状态之间的相关性。
术前糖尿病状态和参数与动脉期密度（p=0.004）、A/P 比和胰管大小（p<0.0001）密切相关。在接受胰切除术的患者中，25 例术前无糖尿病（DM）的患者中有 2 例发生 DM，7 例术前 DM 的患者中有 2 例 DM 恢复。胰切除术后 1 年 CT 参数与 DM 状态相关。
CT 是评估胰腺内分泌功能的一种有用的方法，可用于预测术后糖尿病的结局。
