• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

急性冠状动脉综合征患者低钠血症的短期和长期预后价值：系统评价和荟萃分析。

Short- and long-term prognostic value of hyponatremia in patients with acute coronary syndrome: A systematic review and meta-analysis.

机构信息

Department of Cardiology, Xi'an Central Hospital, Xi'an, Shaanxi Province, China.

Department of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi Province, China.

出版信息

PLoS One. 2018 Mar 2;13(3):e0193857. doi: 10.1371/journal.pone.0193857. eCollection 2018.

DOI:10.1371/journal.pone.0193857
PMID:29499058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5834161/
Abstract

Hyponatremia is relevant to heart failure, liver cirrhosis and stroke, but the prognostic value of serum sodium levels in patients with acute coronary syndrome are still unclear. So we did a systematic review and meta-analysis to assess the prognostic value of hyponatremia on adverse events in patients after ACS. We systematically searched PubMed, Embase and Cochrane Library to find literatures which studied the prognostic value of hyponatremia in patients with ACS. Our main endpoints were the all-cause mortality and heart failure in the short- and long-term. Of 369 identified studies, 20 studies were included in our analysis. Compared with the normal natrium, hyponatremia was significantly associated with the increased risks of all-cause mortality within 30 days (RR: 2.18; 95%CI: 1.96-2.42) and during the follow-ups (HR: 1.74; 95%CI: 1.56-1.942). For the second endpoint of short- and long-term heart failure, the pooled effect sizes in hyponatremia patients were 1.72(95%CI: 1.38-2.14) and 1.69(95%CI: 1.12-2.55) respectively. In conclusion, hyponatremia has a significant prognostic value for short- and long-term adverse event in patients after ACS, the dynamic monitoring of serum sodium levels may could help physicians to identify high risk ACS patients and to stratify risk for optimal management.

摘要

低钠血症与心力衰竭、肝硬化和中风有关，但急性冠状动脉综合征患者血清钠水平的预后价值仍不清楚。因此，我们进行了系统评价和荟萃分析，以评估低钠血症对 ACS 后患者不良事件的预后价值。我们系统地检索了 PubMed、Embase 和 Cochrane Library，以找到研究 ACS 患者低钠血症预后价值的文献。我们的主要终点是短期和长期的全因死亡率和心力衰竭。在 369 项确定的研究中，有 20 项研究纳入了我们的分析。与正常钠水平相比，低钠血症与 30 天内全因死亡率（RR：2.18；95%CI：1.96-2.42）和随访期间（HR：1.74；95%CI：1.56-1.942）增加的风险显著相关。对于短期和长期心力衰竭的第二个终点，低钠血症患者的汇总效应大小分别为 1.72（95%CI：1.38-2.14）和 1.69（95%CI：1.12-2.55）。总之，低钠血症对 ACS 后患者短期和长期不良事件具有显著的预后价值，血清钠水平的动态监测可能有助于医生识别高危 ACS 患者，并对最佳管理进行风险分层。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/25d655361f37/pone.0193857.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/2d76a3d78558/pone.0193857.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/7cd5c842d384/pone.0193857.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/9140b3f01b35/pone.0193857.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/1be8f3f3518b/pone.0193857.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/d9bb6e9308f3/pone.0193857.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/6098856ccb5b/pone.0193857.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/eeba44b5470e/pone.0193857.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/0b8cdfd9ed9b/pone.0193857.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/3aa276112f9b/pone.0193857.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/25d655361f37/pone.0193857.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/2d76a3d78558/pone.0193857.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/7cd5c842d384/pone.0193857.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/9140b3f01b35/pone.0193857.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/1be8f3f3518b/pone.0193857.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/d9bb6e9308f3/pone.0193857.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/6098856ccb5b/pone.0193857.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/eeba44b5470e/pone.0193857.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/0b8cdfd9ed9b/pone.0193857.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/3aa276112f9b/pone.0193857.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df9/5834161/25d655361f37/pone.0193857.g010.jpg

相似文献

1
Short- and long-term prognostic value of hyponatremia in patients with acute coronary syndrome: A systematic review and meta-analysis.急性冠状动脉综合征患者低钠血症的短期和长期预后价值：系统评价和荟萃分析。
PLoS One. 2018 Mar 2;13(3):e0193857. doi: 10.1371/journal.pone.0193857. eCollection 2018.
2
Beta-blockers in patients without heart failure after myocardial infarction.心肌梗死后无心力衰竭的患者使用β受体阻滞剂。
Cochrane Database Syst Rev. 2021 Nov 5;11(11):CD012565. doi: 10.1002/14651858.CD012565.pub2.
3
Non-invasive positive pressure ventilation for central sleep apnoea in adults.成人中枢性睡眠呼吸暂停的无创正压通气。
Cochrane Database Syst Rev. 2022 Oct 24;10(10):CD012889. doi: 10.1002/14651858.CD012889.pub2.
4
Systemic corticosteroids for the treatment of COVID-19: Equity-related analyses and update on evidence.全身性皮质类固醇治疗 COVID-19：与公平相关的分析和证据更新。
Cochrane Database Syst Rev. 2022 Nov 17;11(11):CD014963. doi: 10.1002/14651858.CD014963.pub2.
5
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
6
The comparative and added prognostic value of biomarkers to the Revised Cardiac Risk Index for preoperative prediction of major adverse cardiac events and all-cause mortality in patients who undergo noncardiac surgery.生物标志物对改良心脏风险指数在预测非心脏手术患者主要不良心脏事件和全因死亡率方面的比较和附加预后价值。
Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD013139. doi: 10.1002/14651858.CD013139.pub2.
7
Interventions for chronic non-hypovolaemic hypotonic hyponatraemia.慢性非低血容量性低渗性低钠血症的干预措施。
Cochrane Database Syst Rev. 2018 Jun 28;6(6):CD010965. doi: 10.1002/14651858.CD010965.pub2.
8
Exercise-based cardiac rehabilitation for coronary heart disease.基于运动的冠心病心脏康复。
Cochrane Database Syst Rev. 2021 Nov 6;11(11):CD001800. doi: 10.1002/14651858.CD001800.pub4.
9
Selective noradrenaline reuptake inhibitors for schizophrenia.用于治疗精神分裂症的选择性去甲肾上腺素再摄取抑制剂。
Cochrane Database Syst Rev. 2018 Jan 25;1(1):CD010219. doi: 10.1002/14651858.CD010219.pub2.
10
Sertindole for schizophrenia.用于治疗精神分裂症的舍吲哚。
Cochrane Database Syst Rev. 2005 Jul 20;2005(3):CD001715. doi: 10.1002/14651858.CD001715.pub2.

引用本文的文献

1
Hyponatraemia in ageing.衰老过程中的低钠血症
Nat Rev Endocrinol. 2025 Jun 17. doi: 10.1038/s41574-025-01138-4.
2
Long-Term Clinical Relevance of Hyponatremia Identified During Acute Phase of Myocardial Infarction.心肌梗死急性期发现的低钠血症的长期临床相关性。
J Clin Med. 2025 Feb 3;14(3):962. doi: 10.3390/jcm14030962.
3
Hyponatremia after COVID-19 is frequent in the first year and increases re-admissions.感染新冠病毒后第一年易发生低钠血症，且增加再入院率。

本文引用的文献

1
Prognostic impact of hyponatremia occurring at various time points during hospitalization on mortality in patients with acute myocardial infarction.急性心肌梗死患者住院期间不同时间点发生低钠血症对死亡率的预后影响。
Medicine (Baltimore). 2017 Jun;96(23):e7023. doi: 10.1097/MD.0000000000007023.
2
Hyponatremia at discharge as a predictor of 12-month clinical outcomes in hospital survivors after acute myocardial infarction.出院时低钠血症作为急性心肌梗死医院幸存者12个月临床结局的预测指标
Heart Vessels. 2017 Feb;32(2):126-133. doi: 10.1007/s00380-016-0854-6. Epub 2016 Jun 2.
3
Global and regional patterns in cardiovascular mortality from 1990 to 2013.
Sci Rep. 2024 Jan 5;14(1):595. doi: 10.1038/s41598-023-50970-z.
4
Hyponatremia in patients with arterial hypertension: pathophysiology and management.动脉高血压患者的低钠血症：病理生理学与管理
Arch Med Sci. 2023 Mar 26;19(6):1630-1645. doi: 10.5114/aoms/161578. eCollection 2023.
5
Integrated bioinformatics and machine learning algorithms reveal the critical cellular senescence-associated genes and immune infiltration in heart failure due to ischemic cardiomyopathy.整合生物信息学和机器学习算法揭示了缺血性心肌病心力衰竭中与细胞衰老相关的关键基因和免疫浸润。
Front Immunol. 2023 May 10;14:1150304. doi: 10.3389/fimmu.2023.1150304. eCollection 2023.
6
A step-by-step guide for the diagnosis and management of hyponatraemia in patients with stroke.卒中患者低钠血症诊断与管理的分步指南
Ther Adv Endocrinol Metab. 2023 Apr 3;14:20420188231163806. doi: 10.1177/20420188231163806. eCollection 2023.
7
Impact of cardiac and noncardiac cirrhosis on coronary revascularization outcomes from the National Inpatient Sample, 2016 to 2018.2016年至2018年全国住院患者样本中心脏性和非心脏性肝硬化对冠状动脉血运重建结局的影响
Proc (Bayl Univ Med Cent). 2022 Nov 17;36(2):195-200. doi: 10.1080/08998280.2022.2139989. eCollection 2023.
8
Hyponatremia and Cancer: From Bedside to Benchside.低钠血症与癌症：从床边到实验室
Cancers (Basel). 2023 Feb 13;15(4):1197. doi: 10.3390/cancers15041197.
9
Shape of the association between preoperative hemoglobin level and postoperative outcomes in patients undergoing primary arthroplasty.术前血红蛋白水平与初次关节置换术后患者术后结局之间的关系的形态。
Can J Surg. 2022 Jan 18;65(1):E25-E37. doi: 10.1503/cjs.020720. Print 2022 Jan-Feb.
10
Hyponatremia and Oxidative Stress.低钠血症与氧化应激
Antioxidants (Basel). 2021 Nov 4;10(11):1768. doi: 10.3390/antiox10111768.
1990 年至 2013 年全球和各区域心血管疾病死亡率模式。
Circulation. 2015 Oct 27;132(17):1667-78. doi: 10.1161/CIRCULATIONAHA.114.008720.
4
Hyponatremia in acute heart failure: a marker of poor condition or a mediator of poor outcome?急性心力衰竭中的低钠血症：病情不佳的标志物还是不良结局的介导因素？
Korean J Intern Med. 2015 Jul;30(4):450-2. doi: 10.3904/kjim.2015.30.4.450. Epub 2015 Jun 29.
5
Hyponatraemia on admission to hospital is associated with increased long-term risk of mortality in survivors of myocardial infarction.入院时低钠血症与心肌梗死幸存者长期死亡风险增加有关。
Eur J Prev Cardiol. 2015 Nov;22(11):1419-26. doi: 10.1177/2047487314557963. Epub 2014 Nov 11.
6
Predictors of long-term (10-year) mortality postmyocardial infarction: age-related differences. Soroka Acute Myocardial Infarction (SAMI) Project.心肌梗死后长期（10年）死亡率的预测因素：年龄差异。索罗卡急性心肌梗死（SAMI）项目。
J Cardiol. 2015 Mar;65(3):216-23. doi: 10.1016/j.jjcc.2014.06.001. Epub 2014 Jun 30.
7
Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people.血压与十二种心血管疾病的发病率：125万人的终生风险、健康生命年损失及特定年龄关联
Lancet. 2014 May 31;383(9932):1899-911. doi: 10.1016/S0140-6736(14)60685-1.
8
Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis.中度低钠血症与死亡率增加相关：来自荟萃分析的证据。
PLoS One. 2013 Dec 18;8(12):e80451. doi: 10.1371/journal.pone.0080451. eCollection 2013.
9
Hyponatremia in the prognosis of acute ischemic stroke.低钠血症与急性缺血性脑卒中预后的关系。
J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):850-4. doi: 10.1016/j.jstrokecerebrovasdis.2013.07.011. Epub 2013 Aug 15.
10
Outcomes of correcting hyponatremia in patients with myocardial infarction.纠正心肌梗死患者低钠血症的结果。
Clin Res Cardiol. 2013 Sep;102(9):637-44. doi: 10.1007/s00392-013-0576-z. Epub 2013 May 8.