类器官模型为癌症研究带来无限可能。
Organoid Models of Cancer Explode with Possibilities.
机构信息
Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
出版信息
Cell Stem Cell. 2018 Mar 1;22(3):290-291. doi: 10.1016/j.stem.2018.02.010.
PMID:29499146
Abstract
Organoids have tremendous promise for modeling human cancers and revealing new biological insights. Sachs et al. (2018), Seino et al. (2018) (in this issue of Cell Stem Cell), and Broutier et al. (2017) derive cancer organoids from breast, pancreas, and liver, respectively, not only reporting new methodologies but also showing their utility for translational and clinical cancer research.
摘要
类器官在模拟人类癌症和揭示新的生物学见解方面具有巨大的潜力。Sachs 等人（2018 年）、Seino 等人（2018 年）（本期《细胞-干细胞》）和 Broutier 等人（2017 年）分别从乳腺、胰腺和肝脏中提取了癌症类器官，不仅报道了新的方法，还展示了它们在转化和临床癌症研究中的应用。
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