Department of Biosystems Science and Engineering, ETH Zurich, CH-4058 Basel, Switzerland; Tissue Engineering, Department of Biomedicine, University of Basel and University Hospital Basel, CH-4056 Basel, Switzerland.
Tissue Engineering, Department of Biomedicine, University of Basel and University Hospital Basel, CH-4056 Basel, Switzerland.
Cell Stem Cell. 2018 Mar 1;22(3):298-301. doi: 10.1016/j.stem.2018.01.002.
Recent advances in engineering complex organs in vitro inspire the development of human bone marrow equivalents to foster scientific discovery and innovative therapeutics. Here, we discuss challenges in generating relevant human bone marrow proxies, potential design principles, and future directions.
近年来,体外工程复杂器官的技术进展激发了人类骨髓等效物的开发,以促进科学发现和创新疗法。在这里,我们讨论了生成相关人类骨髓替代物的挑战、潜在的设计原则和未来方向。