Columbia University, New York, USA.
Columbia University, New York, USA.
Adv Drug Deliv Rev. 2019 Feb 1;140:78-92. doi: 10.1016/j.addr.2019.04.003. Epub 2019 Apr 17.
Tissue engineering is becoming increasingly successful in providing in vitro models of human tissues that can be used for ex vivo recapitulation of functional tissues as well as predictive testing of drug efficacy and safety. From simple tissue models to microphysiological platforms comprising multiple tissue types connected by vascular perfusion, these "tissues on a chip" are emerging as a fast track application for tissue engineering, with great potential for modeling diseases and supporting the development of new drugs and therapeutic targets. We focus here on tissue engineering of the hematopoietic stem and progenitor cell compartment and the malignancies that can develop in the human bone marrow. Our overall goal is to demonstrate the utility and interconnectedness of improvements in bioengineering methods developed in one area of bone marrow studies for the remaining, seemingly disparate, bone marrow fields.
组织工程在提供可用于体外重现功能性组织以及预测药物功效和安全性的人类组织模型方面越来越成功。从简单的组织模型到由血管灌注连接的多种组织类型组成的微生理平台，这些“芯片上的组织”正在成为组织工程的快速应用，具有对疾病建模和支持新药和治疗靶点开发的巨大潜力。我们在这里专注于造血干细胞和祖细胞区室的组织工程以及可在人类骨髓中发展的恶性肿瘤。我们的总体目标是展示在骨髓研究的一个领域中开发的生物工程方法的改进在其余看似不同的骨髓领域中的实用性和相互关联性。
