Owens D R, Vora J P, Heding L G, Luzio S, Ryder R E, Atiea J, Hayes T M
Diabet Med. 1986 Jul-Aug;3(4):326-9. doi: 10.1111/j.1464-5491.1986.tb00773.x.
Six normal subjects received subcutaneous human, porcine, and bovine ultralente insulin (0.30 U/kg) and diluent (control) in randomized order. Plasma glucose, C-peptide, and insulin were measured for 32 h after injection. From 10 h onward human ultralente produced significantly lower plasma glucose levels (p less than 0.05-0.01) compared to bovine ultralente. Porcine ultralente produced an intermediate hypoglycaemic response up to 16 h and was similar to the bovine insulin from 24-32 h. Estimated exogenous insulin concentration was higher (p less than 0.05-0.001) following human ultralente compared to bovine ultralente between 2 and 22 h after injection. Up to 24 h the porcine preparation led to intermediate insulin levels, but becoming identical to bovine ultralente from 28-32 h. Peak mean exogenous insulin values for human, porcine, and bovine ultralente were 0.054, 0.044, and 0.023 nmol/l at 14, 16, and 18 h, respectively, reaching 0.022, 0.013, and 0.013 nmol/l at 32 h. The different pharmacokinetic behaviour of human and bovine ultralente insulin must be considered when initiating treatment with human ultralente or transferring patients from bovine to human ultralente.
六名正常受试者按随机顺序接受皮下注射人、猪和牛的超长效胰岛素（0.30U/kg）及稀释剂（对照）。注射后32小时内测定血浆葡萄糖、C肽和胰岛素水平。从10小时起，与人超长效胰岛素相比，牛超长效胰岛素使血浆葡萄糖水平显著降低（p＜0.05 - 0.01）。猪超长效胰岛素在16小时内产生中等程度的降血糖反应，在24 - 32小时与牛胰岛素相似。注射后2至22小时，与人超长效胰岛素相比，牛超长效胰岛素的估计外源性胰岛素浓度更高（p＜0.05 - 0.001）。直至24小时，猪制剂导致中等胰岛素水平，但在28 - 32小时与牛超长效胰岛素相同。人、猪和牛超长效胰岛素的平均外源性胰岛素峰值分别在14、16和18小时为0.054、0.044和0.023nmol/l，在32小时分别降至0.022、0.013和0.013nmol/l。开始用人超长效胰岛素治疗或从牛超长效胰岛素转换为用人超长效胰岛素治疗患者时，必须考虑人及牛超长效胰岛素不同的药代动力学行为。
