Rizza R A, O'Brien P C, Service F J
Diabetes Care. 1986 Mar-Apr;9(2):120-3. doi: 10.2337/diacare.9.2.120.
Ultralente has been used as the basal component of intensive insulin therapy programs. To determine the degree to which a single daily subcutaneous injection of beef ultralente provides stable basal insulin concentrations, plasma free insulin concentrations were measured in six insulin-dependent diabetic patients over a 40-h period. All short-acting insulin was withheld during this interval. Each patient had been maintained on a chronic ultralente based program before study. Little if any evidence of a temporal peak in plasma insulin concentrations was observed. Although considerable variation in plasma insulin concentrations was observed in one individual, beef ultralente provided relatively stable plasma insulin concentrations in the group as a whole. Beef ultralente appears to be a reasonable insulin preparation to use as the basal component in an intensive insulin therapy program.
超长效胰岛素已被用作强化胰岛素治疗方案的基础成分。为了确定每日一次皮下注射牛超长效胰岛素能在多大程度上提供稳定的基础胰岛素浓度，在40小时期间对6名胰岛素依赖型糖尿病患者的血浆游离胰岛素浓度进行了测量。在此期间停用了所有短效胰岛素。每位患者在研究前一直采用基于超长效胰岛素的慢性治疗方案。几乎没有观察到血浆胰岛素浓度出现时间峰值的证据。尽管在一名个体中观察到血浆胰岛素浓度有相当大的变化，但牛超长效胰岛素在整个组中提供了相对稳定的血浆胰岛素浓度。牛超长效胰岛素似乎是一种合理的胰岛素制剂，可作为强化胰岛素治疗方案中的基础成分使用。
