SIDS and Sleep Apnea Laboratory, Sydney Medical School, Medical Foundation Building K25, University of Sydney, NSW 2006, Australia.
School of Life Sciences, Faculty of Science, University of Technology Sydney, Broadway, NSW 2007, Australia.
Neurotoxicology. 2018 Mar;65:186-195. doi: 10.1016/j.neuro.2018.02.014. Epub 2018 Mar 2.
Nicotine is the major neurotoxicant in cigarettes that affects many transmitter systems within the brain as well as other factors, including the growth factors. Brain derived neurotrophic factor (BDNF), is the most abundant growth factor in the brain and plays a critical role in early new neuron differentiation, development and synapsis growth, and the survival of fully developed neurons and synaptic activity. Over the past 3 decades, data has emerged on the effects of nicotine and cigarette smoke exposure on the expression of BDNF and its primary specific receptor tyrosine kinase receptor B (TrkB). This review summarizes data regarding the changes in brain BDNF expression after nicotine or cigarette smoke exposure, and discusses their implications considering BDNF's functional roles.
尼古丁是香烟中的主要神经毒素，它会影响大脑中的许多递质系统以及其他因素，包括生长因子。脑源性神经营养因子（BDNF）是大脑中含量最丰富的生长因子，在早期新神经元分化、发育和突触生长以及成熟神经元的存活和突触活性中起着关键作用。在过去的 30 年中，出现了关于尼古丁和香烟烟雾暴露对 BDNF 及其主要特异性受体酪氨酸激酶受体 B（TrkB）表达影响的数据。这篇综述总结了尼古丁或香烟烟雾暴露后大脑 BDNF 表达变化的数据，并考虑到 BDNF 的功能作用讨论了它们的意义。
