CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation.
作者信息
Le Coz Carole, Trofa Melissa, Syrett Camille M, Martin Anna, Jyonouchi Harumi, Jyonouchi Soma, Anguera Montserrat C, Romberg Neil
机构信息
Division of Immunology and Allergy, The Children's Hospital of Philadelphia, Philadelphia, Pa.
Department of Biomedical Sciences, School of Veterinary Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
出版信息
J Allergy Clin Immunol. 2018 Jun;141(6):2308-2311.e7. doi: 10.1016/j.jaci.2018.02.010. Epub 2018 Mar 2.
Abstract
摘要
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本文引用的文献
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Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X.X染色体失活的异常维持使女性淋巴细胞中失活X染色体的表达增加。
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2029-38. doi: 10.1073/pnas.1520113113. Epub 2016 Mar 21.
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Derivation of consensus inactivation status for X-linked genes from genome-wide studies.从全基因组研究中推导X连锁基因的一致失活状态
Biol Sex Differ. 2015 Dec 30;6:35. doi: 10.1186/s13293-015-0053-7. eCollection 2015.
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Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: a cross-sectional and longitudinal study.狼疮中T淋巴细胞凋亡增加与疾病活动相关，可能是T细胞频率降低的原因：一项横断面和纵向研究。
Lupus. 2009 Aug;18(9):785-91. doi: 10.1177/0961203309103152.
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Demethylation of CD40LG on the inactive X in T cells from women with lupus.狼疮女性T细胞中失活X染色体上CD40LG的去甲基化
J Immunol. 2007 Nov 1;179(9):6352-8. doi: 10.4049/jimmunol.179.9.6352.
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Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.环孢素A抑制T淋巴细胞中CD40配体的表达。
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A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome.来自人类X染色体失活中心区域的一个基因仅从失活的X染色体表达。
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