自身免疫性 GFAP 星形胶质细胞病继发于病毒性脑炎：一例报告。
Autoimmune GFAP astrocytopathy after viral encephalitis: A case report.
机构信息
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Mult Scler Relat Disord. 2018 Apr;21:84-87. doi: 10.1016/j.msard.2018.02.020. Epub 2018 Feb 19.
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune disease. This is the first report of a case of autoimmune GFAP astrocytopathy after herpes simplex viral encephalitis (HSVE). A 35-year-old female patient presented with a combination of headache, fever, seizure and psychiatric/behavioral abnormalities. She had GFAP-IgG in both serum and cerebrospinal fluid (CSF). Magnetic resonance imaging (MRI) with gadolinium-enhancement revealed linear enhancement oriented radially to the ventricles. After treatment with corticosteroids, her symptoms were alleviated, the lesions enhancement reduced, and the immunoreactive intensity of GFAP-IgG decreased. This case shows an observational link between HSVE and autoimmune GFAP astrocytopathy, suggesting that autoimmune GFAP astrocytopathy may provide a new differential diagnosis for relapsing HSVE.
自身免疫性神经胶质纤维酸性蛋白（GFAP）星形胶质细胞病是一种新型自身免疫性疾病。这是首例单纯疱疹病毒性脑炎（HSVE）后自身免疫性 GFAP 星形胶质细胞病的报告。一名 35 岁女性患者出现头痛、发热、癫痫发作和精神/行为异常的症状。她的血清和脑脊液（CSF）中均存在 GFAP-IgG。钆增强磁共振成像（MRI）显示呈线性增强，方向为向脑室放射。皮质类固醇治疗后，她的症状缓解，病灶增强减少，GFAP-IgG 的免疫反应强度降低。该病例显示 HSVE 与自身免疫性 GFAP 星形胶质细胞病之间存在观察性关联，表明自身免疫性 GFAP 星形胶质细胞病可能为复发性 HSVE 提供新的鉴别诊断。
Zotero 插件