Li Weijia, Lin Yuan, Xu Tan, Xilifu Mamatili
Department of Intensive Care Unit, Peking University Shenzhen Hospital, No. 1120, Lianhua Road, Futian District, Shenzhen 518000, China.
Department of Cardiology, Peking University Shenzhen Hospital, No. 1120, Lianhua Road, Futian District, Shenzhen 518000, China.
IDCases. 2025 Jun 24;41:e02303. doi: 10.1016/j.idcr.2025.e02303. eCollection 2025.
Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is an autoimmune-mediated neurological disease with cerebrospinal fluid GFAP-IgG as a marker. This is a rare disease. This paper reported a GFAP-A patient suspected intracranial infection whose diagnosis and treatment were summarized, and the value of negative metagenomic second-generation sequencing (mNGS) results for the exclusion of infectious diseases and the preferred treatment plan for GFAP-A were discussed.
自身免疫性胶质纤维酸性蛋白星形细胞病（GFAP-A）是一种以脑脊液GFAP-IgG为标志物的自身免疫介导的神经系统疾病。这是一种罕见病。本文报道了1例疑似颅内感染的GFAP-A患者，总结了其诊断和治疗过程，并探讨了宏基因组二代测序（mNGS）阴性结果在排除感染性疾病方面的价值以及GFAP-A的首选治疗方案。
