Subdirección de Investigaciones Clínicas, Laboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, Ciudad de México, 14370, Mexico.
Subdirección de Investigaciones Clínicas, Laboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, Ciudad de México, 14370, Mexico.
J Psychiatr Res. 2018 May;100:88-98. doi: 10.1016/j.jpsychires.2018.02.024. Epub 2018 Feb 23.
Psychoactive substance abuse is a health problem worldwide. Has been reported a high prevalence of use of tobacco and cocaine, either separately or in combination. Clinical and animal studies have suggested that the concurrent use of cocaine and nicotine reinforces the potency of one or both drugs and that nicotine may enhance the reinforcing effects of cocaine. Our study evaluated the combined effects of cocaine and nicotine on locomotor activity during the induction and expression phases of locomotor sensitization-a physiological mechanism that plays an important role in establishing some of the defining characteristics of drug abuse.
We used Wistar rats which were dosed with cocaine, nicotine or cocaine and nicotine combination and recorded their locomotor activity in different phases of the experiment.
We found that a daily dose of cocaine combined with nicotine enhanced cocaine- and nicotine-induced locomotor activity, as well as induction and expression of locomotor sensitization. Moreover, we found that pretreatment with nicotine enhanced the locomotor sensitization expression.
These results suggest that concurrent use of cocaine and nicotine may result in co-abuse of these drugs.
精神活性物质滥用是一个全球性的健康问题。据报道，烟草和可卡因的使用率都很高，要么单独使用，要么联合使用。临床和动物研究表明，可卡因和尼古丁的同时使用增强了一种或两种药物的效力，并且尼古丁可能增强可卡因的强化作用。我们的研究评估了可卡因和尼古丁联合使用对运动敏感化诱导和表达阶段的运动活动的影响——运动敏感化是一种在建立药物滥用的一些特征方面起着重要作用的生理机制。
我们使用 Wistar 大鼠，给予可卡因、尼古丁或可卡因和尼古丁混合物，并在实验的不同阶段记录它们的运动活动。
我们发现，每日剂量的可卡因与尼古丁联合使用增强了可卡因和尼古丁引起的运动活动，以及运动敏感化的诱导和表达。此外，我们发现，尼古丁预处理增强了运动敏感化的表达。
这些结果表明，可卡因和尼古丁的同时使用可能导致这些药物的共同滥用。
