Yamamoto H, Komatsuzaki T
Jikken Dobutsu. 1987 Jan;36(1):17-25. doi: 10.1538/expanim1978.36.1_17.
The pathological examination of the rabbit knee joint with antigen-induced arthritis produced by heat-killed Streptococcus faecalis (Str. faec.) as antigen was carried out. Macroscopically, there were findings of acute inflammation about five hours after the injection. Histopathologically, very remarkable acute exudative inflammation was seen 48 hours later. This supported the picture of Arthus reaction. The Arthus reaction disappeared with time, and this supported the view of delayed-type hypersensitivity three weeks later. After that, an obvious chronic inflammation was admitted in 10 weeks. This resembled the histopathological feature of rheumatoid arthritis (RA) when these findings are summarized. It was suggested that arthritis produced by Str. faec. progresses from an acute condition to a one with time. As mentioned above, it thought that Arthus reaction of both immediate hypersensitivity and delayed-type hypersensitivity are necessary in the occurrence of this arthritis.
对以热灭活粪链球菌（Str. faec.）作为抗原诱导产生关节炎的兔膝关节进行了病理检查。宏观上，注射后约5小时出现急性炎症表现。组织病理学上，48小时后可见非常显著的急性渗出性炎症。这支持了阿瑟斯反应的表现。阿瑟斯反应随时间消失，这支持了3周后迟发型超敏反应的观点。此后，10周时出现明显的慢性炎症。总结这些发现时，这类似于类风湿性关节炎（RA）的组织病理学特征。提示粪链球菌引起的关节炎随时间从急性状态发展为慢性状态。如上所述，认为速发型超敏反应和迟发型超敏反应的阿瑟斯反应在这种关节炎的发生中都是必要的。
