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基于响应面法和力学行为模拟优化超高分子量聚乙烯纳米复合材料髋关节衬垫的注塑工艺。

Optimization simulated injection molding process for ultrahigh molecular weight polyethylene nanocomposite hip liner using response surface methodology and simulation of mechanical behavior.

机构信息

Applied Science Nano Research Group, ASNARKA, P.C. 1619948753, Tehran, Iran.

Department of Chemical and Polymer Engineering, Faculty of Engineering, Central Tehran Branch, Islamic Azad University, P.O. Box 13185-768, Tehran, Iran; Soft Tissue Engineering Research Center, Tissue Engineering and Regenerative Medicine Institute, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

出版信息

J Mech Behav Biomed Mater. 2018 May;81:95-105. doi: 10.1016/j.jmbbm.2018.02.025. Epub 2018 Feb 21.

DOI:10.1016/j.jmbbm.2018.02.025
PMID:29500982
Abstract

In this study, injection molding process of ultrahigh molecular weight polyethylene (UHMWPE) reinforced with nano-hydroxyapatite (nHA) was simulated and optimized through minimizing the shrinkage and warpage of the hip liners as an essential part of a hip prosthesis. Fractional factorial design (FFD) was applied to the design of the experiment, modeling, and optimizing the shrinkage and warpage of UHMWPE/nHA composite liners. The Analysis of variance (ANOVA) was applied to find the importance of operative parameters and their effects. In this experiment, seven input parameters were surveyed, including mold temperature (A), melt temperature (B), injection time (C), packing time (D), packing pressure (E), coolant temperature (F), and type of liner (G). Two models were capable of predicting warpage and volumetric shrinkage (%) in different conditions with R of 0.9949 and 0.9989, respectively. According to the models, the optimized values of warpage and volumetric shrinkage are 0.287222 mm and 13.6613%, respectively. Meanwhile, a finite element analysis (FE analysis) was also carried out to examine the stress distribution in liners under the force values of demanding and daily activities. The Von-Mises stress distribution showed that both of the liners can be applied to all activities with no failure. However, UHMWPE/nHA liner is more resistant to the highest loads than UHMWPE liner due to the effect of nHA in the nanocomposite. Finally, according to the results of injection molding simulations, optimization, structural analysis as well as the tensile strength and wear resistance, UHMWPE/nHA liner is recommended for the production of a hip prosthesis.

摘要

本研究通过最小化髋关节衬垫的收缩和翘曲,模拟并优化了超高分子量聚乙烯(UHMWPE)增强纳米羟基磷灰石(nHA)的注塑成型工艺,髋关节衬垫是髋关节假体的重要组成部分。分数阶因子设计(FFD)应用于实验设计、建模和优化 UHMWPE/nHA 复合衬垫的收缩和翘曲。方差分析(ANOVA)用于确定操作参数的重要性及其影响。在该实验中,调查了七个输入参数,包括模具温度(A)、熔体温度(B)、注射时间(C)、保压时间(D)、保压压力(E)、冷却水温(F)和衬垫类型(G)。两个模型能够在不同条件下预测翘曲和体积收缩率(%),其 R 分别为 0.9949 和 0.9989。根据模型,优化后的翘曲和体积收缩率分别为 0.287222 mm 和 13.6613%。同时,还进行了有限元分析(FE 分析),以检查在需求和日常活动力值下衬套中的应力分布。Von-Mises 应力分布表明,两种衬垫都可以应用于所有活动而不会失效。然而,由于纳米复合材料中 nHA 的作用,UHMWPE/nHA 衬垫比 UHMWPE 衬垫更能抵抗最高负荷。最后,根据注塑成型模拟、优化、结构分析以及拉伸强度和耐磨性的结果,推荐使用 UHMWPE/nHA 衬垫来生产髋关节假体。

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