Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Neuroscience Research Institute of SNUMRC, College of Medicine, Seoul National University, Seoul, South Korea.
Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Department of Neurology, National Center for Mental Health, an Affiliate of the Ministry for Health and Welfare, Seoul, South Korea.
J Neuroimmunol. 2018 Apr 15;317:8-14. doi: 10.1016/j.jneuroim.2018.02.005. Epub 2018 Feb 7.
The aim of this study was to analyze the detailed characteristics of the psychiatric symptoms in patients with anti-LGI1 encephalitis. Of 16 patients, ten showed psychiatric symptoms as the initial manifestations. All 10 patients experienced mood-related symptoms. The time to immune therapy was longer in those with initial psychiatric symptoms compared to those without them. Initial manifestation of psychiatric symptoms in patients with anti-LGI1 encephalitis may be a poor prognostic factor, at least in the short term, in that it misleads both the patients and the clinicians to neglect the typically accompanied symptoms of the disease such as faciobrachial dystonic seizure, delaying the timing of immune therapy.
本研究旨在分析抗 LGI1 脑炎患者精神病症状的详细特征。16 名患者中，有 10 名以精神病症状为首发表现。所有 10 名患者均出现与情绪相关的症状。与无首发精神病症状者相比，首发精神病症状患者接受免疫治疗的时间更长。抗 LGI1 脑炎患者首发精神病症状可能是一个不良预后因素，至少在短期内是如此，因为它会误导患者和临床医生忽视该病通常伴随的症状，如面肩臂肌张力障碍发作，从而延迟免疫治疗的时机。
