Bae Mi Hye, Jang Hyun Ji, Lee Na Rae, Han Young Mi, Byun Shin Yun, Park Kyung Hee
Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea.
Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine, Yangsan, South Korea.
Pediatr Neonatol. 2018 Dec;59(6):606-610. doi: 10.1016/j.pedneo.2018.02.006. Epub 2018 Feb 13.
Periventricular echogenicity (PVE) presents as diffuse echo dense lesions of the periventricular white matter on cranial ultrasonography. Beyond two weeks of life, it is considered as prolonged or persistent PVE. The aim of our study was to investigate the clinical characteristics of preterm infants with persistent PVE beyond 2 weeks after birth and to determine whether these infants had an adverse neurodevelopmental outcome.
The medical records of preterm infants who were born at < 34 weeks of gestation and admitted to Pusan National University Hospital between 2009 and 2014 were reviewed. A total of 28 preterm infants with persistent PVE were enrolled. Sixty compatible infants closely matched for gestational age and birth weight to infants with PVE were selected as the control group. Clinical data, including maternal, perinatal and neonatal characteristics, were analyzed. We compared the Bayley Scales of Infant Development-III at 12 months' corrected age.
The mean gestational age and birth weight were 31 + 3 (range, 29 + 2-33 + 6) weeks and 1523 (range, 911-2210) g, respectively, in the persistent PVE group. In the control group, the mean gestational age was 31 + 4 (range, 29 + 2-33 + 6) weeks and the mean birth weight was 1537 (range, 840-2100) g. There was no significant difference between the persistent PVE group and the control group, except for a significantly higher incidence of late sepsis in the persistent PVE group (p = 0.001). The results of Bayley test at 12 months of corrected age were available for 24 infants in the persistent PVE group and for 26 infants in the control group. A motor score of 86 (range, 78-95) versus 88 (range, 79-100), a language composite score of 88 (range, 78-97) versus 89 (range, 80-105), and a cognitive score of 90 (range, 81-100) versus 92 (range, 85-105) were observed in the persistent PVE group and the control group, respectively. No difference was detected in any scores between the two groups.
The clinical characteristics and neurodevelopmental outcomes of preterm infants with persistent PVE were not different from those of infants with normal findings. Our study supports the concept that persistent PVE without cystic change may be a benign finding.
脑室周围回声增强（PVE）在头颅超声检查中表现为脑室周围白质弥漫性回声致密病变。出生两周后出现的PVE被认为是延长或持续的PVE。我们研究的目的是调查出生后2周以上患有持续性PVE的早产儿的临床特征，并确定这些婴儿是否有不良神经发育结局。
回顾了2009年至2014年在釜山国立大学医院收治的孕周小于34周的早产儿的病历。共纳入28例患有持续性PVE的早产儿。选择60例胎龄和出生体重与PVE婴儿密切匹配的相符婴儿作为对照组。分析包括母亲、围产期和新生儿特征在内的临床数据。我们比较了校正年龄12个月时的贝利婴儿发育量表第三版。
持续性PVE组的平均胎龄和出生体重分别为31 + 3（范围29 + 2 - 33 + 6）周和1523（范围911 - 2210）g。对照组的平均胎龄为31 + 4（范围29 + 2 - 33 + 6）周，平均出生体重为1537（范围840 - 2100）g。持续性PVE组与对照组之间无显著差异，除了持续性PVE组晚期败血症的发生率显著更高（p = 0.001）。校正年龄12个月时贝利测试的结果可用于持续性PVE组的24例婴儿和对照组的26例婴儿。持续性PVE组和对照组的运动评分分别为86（范围78 - 95）和88（范围79 - 100），语言综合评分分别为88（范围78 - 97）和89（范围80 - 105），认知评分分别为90（范围81 - 100）和92（范围85 - 105）。两组在任何评分上均未检测到差异。
患有持续性PVE的早产儿的临床特征和神经发育结局与检查结果正常的婴儿无异。我们的研究支持无囊性改变的持续性PVE可能是良性发现这一概念。
