早产儿脑室周围回声增强的分级及持续时间与神经发育结局的相关性
Correlation of grading and duration of periventricular echodensities with neurodevelopmental outcome in preterm infants.
作者信息
Resch Bernhard, Jammernegg Andrea, Perl Eva, Riccabona Michael, Maurer Ute, Müller Wilhelm D
机构信息
Division of Neonatology, Department of Paediatrics, Medical University Graz, Auenbruggerplatz 30, 8036, Graz, Austria.
出版信息
Pediatr Radiol. 2006 Aug;36(8):810-5. doi: 10.1007/s00247-006-0178-2. Epub 2006 Jun 10.
BACKGROUND
Transient periventricular echodensities (PVE) in preterm infants affect neurodevelopmental outcome.
OBJECTIVE
To correlate the duration and grading of PVE with neurodevelopmental outcome.
MATERIALS AND METHODS
A retrospective, single-centre cohort study of infants with PVE diagnosed by ultrasonography from 1995 to 2000 with blinded grading and recognition of duration of PVE.
RESULTS
A total of 72 infants (median gestational age 32 weeks, median birth weight 1,668 g) were diagnosed as having PVE. Minor neurological abnormalities were diagnosed in seven (10%), cerebral palsy in six (8%), developmental delay in seven (10%), and mild mental retardation in two (3%) of the infants. Differences regarding adverse outcome were not significant between infants with severity grade 1 compared to severity grade 2 (16% and 22%, respectively). There was a significant increase in adverse neurodevelopmental outcome with increasing duration of PVE. Of 33 infants with duration of PVE<7 days, 1 (3%) had an adverse neurodevelopmental outcome, compared to 6 (24%) of 25 infants with a duration of PVE of 7-14 days, and 6 (43%) of 14 infants with a duration of PVE>14 days (P<0.002, RR 7.920, 95% CI 1.017-61.661; P<0.001, RR 14.143, 95% CI 1.871-106.895, respectively).
CONCLUSION
The duration, but not the grading, of transient PVE was significantly correlated with neurodevelopmental outcome.
背景
早产儿脑室周围短暂性回声增强（PVE）会影响神经发育结局。
目的
将PVE的持续时间和分级与神经发育结局进行关联。
材料与方法
一项回顾性单中心队列研究，研究对象为1995年至2000年经超声诊断为PVE的婴儿，对PVE的持续时间进行盲法分级和识别。
结果
共有72例婴儿（中位胎龄32周，中位出生体重1668克）被诊断为患有PVE。7例（10%）婴儿被诊断为轻度神经异常，6例（8%）为脑瘫，7例（10%）为发育迟缓，2例（3%）为轻度智力低下。1级严重程度的婴儿与2级严重程度的婴儿相比，不良结局差异无统计学意义（分别为16%和22%）。随着PVE持续时间的增加，不良神经发育结局显著增加。PVE持续时间<7天的33例婴儿中，1例（3%）有不良神经发育结局；PVE持续时间为7 - 14天的25例婴儿中，6例（24%）有不良神经发育结局；PVE持续时间>14天的14例婴儿中，6例（43%）有不良神经发育结局（P<0.002，RR 7.920，95%CI 1.017 - 61.661；P<0.001，RR 14.143，95%CI 1.871 - 106.895）。
结论
短暂性PVE的持续时间而非分级与神经发育结局显著相关。
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