糖基化介导的癌症靶向药物递送的进展。
Advances in glycosylation-mediated cancer-targeted drug delivery.
机构信息
Personalized Drug Therapy Key Laboratory of Sichuan Province, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Engineering, Sun Yat-sen University, Guangzhou 510275, China.
出版信息
Drug Discov Today. 2018 May;23(5):1126-1138. doi: 10.1016/j.drudis.2018.02.009. Epub 2018 Feb 28.
Targeted drug delivery for cancer therapy is expected to enhance therapeutic efficacy with minimized side effects, where the ligand-receptor recognition serves as a common targeting approach. Various ligands have been reported and carbohydrates, one of the crucial structures of tumor cell membranes, have been demonstrated effective for cell-selective binding. Hence, glycosylation-mediated cancer-targeted drug nanocarriers have received increasing attention in recent years. This review surveys a variety of glycosylated drug delivery systems as well as their applications for cancer therapy. Their challenges, opportunities, and future perspectives are also discussed in the end.
癌症治疗的靶向药物输送有望提高治疗效果，同时最大限度地减少副作用，其中配体-受体识别是一种常见的靶向方法。已经报道了各种配体，并且糖是肿瘤细胞膜的关键结构之一，已被证明可有效进行细胞选择性结合。因此，近年来糖基化介导的癌症靶向药物纳米载体受到了越来越多的关注。本文综述了各种糖基化药物传递系统及其在癌症治疗中的应用。最后还讨论了它们的挑战、机遇和未来展望。
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