Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Pharmacol Res. 2018 May;131:143-149. doi: 10.1016/j.phrs.2018.02.025. Epub 2018 Mar 1.
Stromal Antigen 2 (STAG2) is one of four components of the cohesin complex and predominantly functions in sister chromatid cohesion and segregation. STAG2 is the most frequently mutated cohesin subunit and was recently identified as a gene that is commonly altered in bladder cancer. The significance of these mutations remains controversial. Some studies associate loss of STAG2 expression with low stage and low grade bladder tumors, as well as with improved clinical outcomes. In other cases, STAG2 inactivation has been shown to be a predictor of worse outcome for these patients. The role of STAG2 in aneuploidy also remains controversial. Loss of STAG2 is associated with significant changes in chromosome number in certain cell lines, while in others, aneuploidy is not induced or results remain inconclusive. At this time, little is known about the influence of STAG2 on cellular migration, invasion, proliferation, and cell death, and such studies are required to determine the role of STAG2 in bladder cancer and other malignancies.
基质抗原 2（STAG2）是黏合蛋白复合体的四个组成部分之一，主要功能是姐妹染色单体的黏合和分离。STAG2 是最常突变的黏合蛋白亚单位，最近被确定为膀胱癌中常见改变的基因。这些突变的意义仍存在争议。一些研究表明，STAG2 表达缺失与低分期、低分级膀胱癌以及临床结局改善有关。在其他情况下，STAG2 失活已被证明是这些患者预后不良的预测因子。STAG2 在非整倍体中的作用也存在争议。在某些细胞系中，STAG2 的缺失与染色体数目的显著变化有关，而在其他细胞系中，非整倍体并未被诱导，或者结果仍不确定。目前，关于 STAG2 对细胞迁移、侵袭、增殖和细胞死亡的影响知之甚少，需要进行这些研究以确定 STAG2 在膀胱癌和其他恶性肿瘤中的作用。
