Farrar W L, Kilian P, Hill J M, Ruff M R, Pert C B
Lymphokine Res. 1987 Winter;6(1):29-34.
Interleukin 1 (IL-1) and the human retrovirus HTLV-III/LAV represent two distinct molecular and biological constituents that are apparently shared by both the immune and central nervous systems. IL-1 is a cytokine produced principally by monocytes of the immune system and glial cells of brain in situ or in vitro. HTLV-III/LAV represents a unique class of human retrovirus which is the recognized etiological vector of acquired immunodeficiency syndrome (AIDS) which exhibits cellular tropism to helper T lymphocytes or brain by the interactions with an entry protein previously described as the T4 antigen. Autoradiography was used to examine the specific binding distribution of 125I-IL-1 alpha and anti-T4 antibody to rat and squirrel monkey brain sections, respectively. Representative data shows unique neuroanatomical distributions of the IL-1 binding protein (receptor) and the T4 antigen in brain. The autoradiographic study provides a qualitative and quantitative analysis of shared receptors between the immune and nervous systems and offers potential for the discovery of new biological or pathological interactions of these common physiological constituents.
白细胞介素1（IL-1）和人类逆转录病毒HTLV-III/LAV代表了两种不同的分子和生物学成分，免疫系统和中枢神经系统显然都有这两种成分。IL-1是一种细胞因子，主要由免疫系统的单核细胞以及脑内或体外的神经胶质细胞产生。HTLV-III/LAV代表一类独特的人类逆转录病毒，它是获得性免疫缺陷综合征（AIDS）公认的病原体载体，通过与一种先前被称为T4抗原的进入蛋白相互作用，对辅助性T淋巴细胞或脑表现出细胞嗜性。分别使用放射自显影术来检测125I-IL-1α和抗T4抗体与大鼠和松鼠猴脑切片的特异性结合分布。代表性数据显示了脑中IL-1结合蛋白（受体）和T4抗原独特的神经解剖分布。放射自显影研究对免疫系统和神经系统之间共享的受体进行了定性和定量分析，并为发现这些常见生理成分新的生物学或病理相互作用提供了可能性。
