Melchers F, Erdei A, Corbel C, Leptin M, Schulz T, Dierich M P
Mol Immunol. 1986 Nov;23(11):1173-6. doi: 10.1016/0161-5890(86)90148-3.
Three restriction points control the cell cycle of activated murine B lymphocytes in a synergistic way. The first is controlled by the occupancy of surface immunoglobulin either by antigen- or by immunoglobulin-specific antibodies. The second is controlled by the complement C3d receptor CR2 which can be occupied by cross-linked C3b or C3d to stimulate the entry into S phase, or by soluble C3d or a C3 alpha-chain peptide, binding to the CR2 receptor, which inhibit the entry into S phase. Macrophages produce so-called alpha factors which also control the B-cell cycle at the same point. Thus, it is suspected that macrophages produce components of the early pathway of complement activation which finally lead to cross-linking of CR2 receptors on B cells. The third restriction point is controlled by unknown receptors that recognize so-called beta factors produced by helper T lymphocytes.
三个限制点以协同方式控制活化的小鼠B淋巴细胞的细胞周期。第一个限制点受表面免疫球蛋白被抗原或免疫球蛋白特异性抗体占据的情况控制。第二个限制点受补体C3d受体CR2控制，交联的C3b或C3d可占据该受体以刺激进入S期，或者可溶性C3d或C3α链肽与CR2受体结合，从而抑制进入S期。巨噬细胞产生所谓的α因子，其也在同一点控制B细胞周期。因此，怀疑巨噬细胞产生补体激活早期途径的成分，最终导致B细胞上CR2受体的交联。第三个限制点由识别辅助性T淋巴细胞产生的所谓β因子的未知受体控制。
