帕金森病中对多巴胺能药物继发性无反应但对丘脑底核刺激仍有反应的意义。
Implications of secondary unresponsiveness to dopaminergic drugs with preserved response to subthalamic nucleus stimulation in Parkinson's disease.
作者信息
Lenka Abhishek, Jhunjhunwala Ketan R, Stezin Albert, Manjunath M, Srinivas Dwarakanath, Yadav Ravi, Pal Pramod K
机构信息
Department of Clinical Neurosciences; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
出版信息
Neurol India. 2018 Mar-Apr;66(Supplement):S135-S137. doi: 10.4103/0028-3886.226454.
Improvement in motor symptoms with levodopa is one of the hallmark features of Parkinson's disease (PD). The response to levodopa may reduce during the course of the illness. Few studies have also reported reduced response to levodopa in patients with PD several years after deep brain stimulation (DBS) of the subthalamic nucleus (STN) on both the sides. In this study, we report an extreme unresponsiveness to levodopa in the presence of a good response to STN stimulation in a patient 5 years after the DBS proceudre had been carried out. The implications of this phenomenon are also discussed.
左旋多巴治疗后运动症状改善是帕金森病（PD）的标志性特征之一。在疾病过程中，对左旋多巴的反应可能会降低。也有少数研究报道，双侧丘脑底核（STN）进行深部脑刺激（DBS）数年的PD患者对左旋多巴的反应降低。在本研究中，我们报告了1例患者在进行DBS手术后5年，对STN刺激反应良好，但对左旋多巴极度无反应。我们还讨论了这一现象的意义。
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